The prestigious journal AJP-Heart and Circulatory Physiology awarded “Flaxseed, its bioactive components and their cardiovascular benefits” as its BEST PAPER AWARD REVIEW ARTICLE for 2020. Congratulations to these world-renowned flax researchers for this well-deserved recognition.
Drs. Mihir Parikh, Thomas Netticadan and Grant N. Pierce, of Winnipeg Manitoba, and affiliated with the Faculty of Health Sciences, University of Manitoba; Canadian Centre for Agri-food Research in Health and Medicine (CCARM) and Agriculture and Agri-Food Canada; and the Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre.
“It’s not only rewarding to be recognized for our work by one of the esteemed cardiovascular physiology journals, but the fact that it was downloaded more than 2500 times shows the favorable interest flaxseed is generating among scientists” said Parikh.
“Being a researcher in the area of cardioprotection using nutritional strategies, I am very pleased and honored to be part of this award winning review paper highlighting the cardiovascular benefits of flaxseed and its components. I ‘d like to thank Dr. Grant Pierce for giving me the opportunity to able to contribute to this paper, and to Mihir Parikh for leading it,” said Netticadan.
The paper won based upon:
Best Paper Score: 655
Total Citations 2018 – 2019: 11
Online article downloads: 2,640 (as of 3/31/20)
Abstract: Cardiovascular disease remains the leading cause of mortality and morbidity worldwide. The inclusion of functional foods and natural health products in the diet are gaining increasing recognition as integral components of lifestyle changes in the fight against cardiovascular disease. Several preclinical and clinical studies have shown the beneficial cardiovascular effects of dietary supplementation with flaxseed. The cardiovascular effects of dietary flaxseed have included an antihypertensive action, antiatherogenic effects, a lowering of cholesterol, an anti-inflammatory action, and an inhibition of arrhythmias. Its enrichment in the ω-3 fatty acid α-linolenic acid and the antioxidant lignan secoisolariciresinol diglucoside as well as its high fiber content have been implicated primarily in these beneficial cardiovascular actions. Although not as well recognized, flaxseed is also composed of other potential bioactive compounds such as proteins, cyclolinopeptides, and cyanogenic glycosides, which may also produce biological actions. These compounds could also be responsible for the cardiovascular effects of flaxseed. This article will not only summarize the cardiovascular effects of dietary supplementation with flaxseed but also review its bioactive compounds in terms of their properties, biological effects, and proposed mechanisms of action. It will also discuss promising research directions for the future to identify additional health-related benefits of dietary flaxseed.
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