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PhD / MSc Students

Graduate students interested in applying to the Msc or Phd programs must register through the Department of Pharmacology & Therapeutics at the University of Manitoba. More information on applying can be found online at the Department of Pharmacology & Therapeutics’ website – http://www.umanitoba.ca/faculties/medicine/units/pharmacology/index.html.

Creating Opportunity by Promoting Research Excellence

The Department of Pharmacology and Therapeutics is dedicated to training highly-qualified, adaptable graduate students and fellows poised to meet the growing worldwide demand for basic science and clinical pharmacologists. We are fully aware that competing for the most desirable career positions, whether academic or industrial, requires a competitive research record. We are all about creating opportunity, and that is why we are committed to excellence in research by actively teaching and encouraging innovation, technical diversity, collaboration and rigorous scientific integrity…all aimed at driving publication of high-impact pharmacological research and generation of intellectual property.

Multi-disciplinary Training

Research in the Department of Pharmacology and Therapeutics encompasses a diverse range of pharmacology sub-disciplines and thus facilitates exposure of trainees to a comprehensive, multi-disciplinary Pharmacology and Therapeutics Graduate Training Program. Our research takes an integrative approach where cell culture, organ and whole animal studies are combined to address complex issues related to drug action and disease. Trainees have opportunities to specialize their research activities to an area of choice, or may tailor a research program toward achieving well-rounded expertise. Regardless of the research area, a tremendous strength of the Department of Pharmacology and Therapeutics is the availability of a wide range of technical approaches for achieving research goals. Molecular and cellular approaches are employed readily by investigators as useful research tools, but we also realize the growing scientific importance and career marketability of being able to test theories in organs and in the whole living organism. Several investigators in the Department of Pharmacology and Therapeutics offer unique opportunities to trainees by utilizing intact organ and/or whole animal pharmacological models to probe mechanisms of disease and novel pharmacological treatments.

Diverse Research Areas

The Department currently houses robust research programs in Cardiovascular Pharmacology, Liver and Endocrine Pharmacology, Neuropharmacology, Drug Metabolism and Clinical Pharmacology at the University of Manitoba Medical Campus, and a specialized research program in the Neuropharmacology of Neurodegenerative Disorders at St. Boniface Hospital Research. Detailed descriptions of research programs can be found on individual Faculty pages. The following are links to general descriptions and current topics of research areas represented in the Department of Pharmacology and Therapeutics:

In addition, individual laboratories are focused on making discoveries that translate to new drug development in specialized areas of pharmacology, including lipid pharmacology, toxicology, cancer pharmacology, asthma pharmacology, nutraceuticals, and muscle regeneration. Contact us to find out more.

1. Cardiovascular Pharmacology

Current Topics:

What is the role of kidneys in blood pressure regulation and hypertension?

What is the role of brain centres in blood pressure regulation?

What is the role of lipids in normal heart function and atherosclerosis?

How do blood clotting mechanisms change in diabetes and other disorders?

What is the role of nitric oxide in paediatric hypertension?

What are the mechanisms of re-perfusion injury in heart following ischemia?

How does conjugated linoleic acid and other functional foods affect heart function and disease?

What are the gene products that cause programmed cell death in heart tissue?

Faculty Involved:

Hope Anderson, Ph.Dhanderson@sbrc.ca
Ratna Bose, Ph.D.rbose@umanitoba.ca
John Docherty, Ph.D.jdocherty@novadh2.ca
Pablo Forte, M.D., Ph.D.pforte@ms.umanitoba.ca
Grant Hatch, Ph.D.hatchgm@umanitoba.ca
Lorrie Kirshenbaum, Ph.D.lorriek@sbrc.ca
Archie McNicol, Ph.D.mcnicol@umanitoba.ca
Brian Penner, M.Dbpenner@umanitoba.ca
Steve Mink, M.D.minksn@umanitoba.ca
Donald Smyth, Ph.D.dsmyth@umanitoba.ca

2. Cardiovascular Pharmacology

Current Topics:

What is the role of kidneys in blood pressure regulation and hypertension?

What is the role of brain centres in blood pressure regulation?

What is the role of lipids in normal heart function and atherosclerosis?

How do blood clotting mechanisms change in diabetes and other disorders?

What is the role of nitric oxide in paediatric hypertension?

What are the mechanisms of re-perfusion injury in heart following ischemia?

How does conjugated linoleic acid and other functional foods affect heart function and disease?

What are the gene products that cause programmed cell death in heart tissue?

Faculty Involved:

Hope Anderson, Ph.Dhanderson@sbrc.ca
Ratna Bose, Ph.D.rbose@umanitoba.ca
John Docherty, Ph.D.jdocherty@novadh2.ca
Pablo Forte, M.D., Ph.D.pforte@ms.umanitoba.ca
Grant Hatch, Ph.D.hatchgm@umanitoba.ca
Lorrie Kirshenbaum, Ph.D.lorriek@sbrc.ca
Archie McNicol, Ph.D.mcnicol@umanitoba.ca
Brian Penner, M.Dbpenner@umanitoba.ca
Steve Mink, M.D.minksn@umanitoba.ca
Donald Smyth, Ph.D.dsmyth@umanitoba.ca

3. Neuropharmacology & Neurodegenerative Disorders

Current Topics:

How does cellular calcium regulation change in Alzheimer’s Disease and diabetes?

What are the mechanisms of synaptic plasticity and how do they translate into learning and memory?

How is synaptic plasticity and its impact on animal behaviour altered in neurodegenerative disorders?

What is the role of the DNA repair enzyme PARP in stroke and Multiple Sclerosis?

What are the mechanisms of nerve degeneration in types 1 and 2 diabetes?

How are adenine nucleotide levels regulated in normal brain and in cerebral ischemia?

What is the structure and function of the blood brain barrier?

How do astrocytes participate in synaptic function and cerebral blood flow regulation?

What is the role of astrocyte D-serine in neuronal injury in stroke and trauma?

Are adenosine receptors viable therapeutic targets for CNS inflammation in Multiple Sclerosis?

Can MRI imaging protocols be developed for early diagnosis of Alzheimer’s Disease?

How does the liver regenerate itself following diseases such as Hepatitis?

How does the liver-derived insulin sensitizing substance contribute to type 2 diabetes?

How does abnormal collagen deposition in liver lead to cirrhosis?

What are the mechanisms of gastrointestinal ulcer formation?

How are lipophilic drugs transported into liver cells, and what is the influence of binding proteins?

(More information on on this topic can be found at our St. Boniface Campus website at www.sbrc.ca/dnd )

Faculty Involved:

Ben Albensi, Ph.Dbalbensi@sbrc.ca
Chris Anderson, Ph.Dcanderson@sbrc.ca
Paul Fernyhough, Ph.D.pfernyhough@sbrc.ca
Gordon Glazner, Ph.D.gglazner@sbrc.ca
Frank LaBella, Ph.D.flabella@mts.net
Melanie Martin, Ph.D.mmartin@uwinnipeg.ca
Don Miller, Ph.D.miller05@umanitoba.ca
Fiona Parkinson, Ph.D.parkins@umanitoba.ca
Jim Peeling, Ph.D.jpeeling@umanitoba.ca

4. Clinical Pharmacology & Drug Metabolism

Current Topics:

Which enzymes contribute to drug metabolism by acetylation?

How are drugs transported into kidney tubules and across the blood-brain barrier?

How does aging affect drug metabolism and efficacy?

How are antimicrobial pharmacokinetics and pharmacodynamics related to clinical outcome?

What are the clinical pharmacology characteristics of antiviral drugs

Faculty Involved:

Daniel Sitar, Ph.D.sitar@umanitoba.ca
Robert Ariano, Pharm.D., BCPS, FCCMrariano@sbgh.mb.ca
Fred Aoki, M.D.nelsonak@umanitoba.ca
Alvaro Bras, Ph.D.
Donald Miller, PhDmiller5@umanitoba.ca

Please visit the Department of Phamacology & Therapeutics website for further information relating to graduate studies at the University of Manitoba.