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Dr. Gordon Glazner

Dr. Gordon Glazner

Principal Investigator
Cellular Neuropathology & Neurodegeneration, Division of Neurodegenerative Disorders

Assistant Professor
Pharmacology & Therapeutics, University of Manitoba

Research Focus

Cellular biologist Dr. Gordon Glazer is investigating protective mechanisms within the cell. When a neuron is under stress, it fights for survival by increasing the production of certain proteins. The balance that is struck between the death-inducing stress and the production of protective proteins will determine whether the cell lives or dies. The production of these proteins is controlled by transcription factors, and one of the most important of these is NF-kappaB. “NF-kappaB is a stressed-induced anti-stress response,” Dr. Glazner explains. “In neurons, NF-kappaB is always fairly high, which isn’t true of other cells. We believe it is important not just for survival but for function of the neuron itself, so discovering the ways in which outside messengers impact on that can be important for our understanding of how the nerve itself works and, in turn, for our understanding of clinical pathologies which involve neuronal death.”

Investigation an end run around cell death

When stressors, such as those caused by stroke or Alzheimer’s disease, activate receptors in the neuron’s endoplasmic reticulum, calcium is released. The release of calcium inside a cell turns on the transcription factor NF-kappaB which acts to protect the cell by stabilizing the calcium. The mechanisms that control the NF-kappaB binding activity are not well understood, and Dr. Glazner’s laboratory is studying the pathways involved.

Dr. Glazer will determine whether the release of calcium increases NF-KappaB binding under stress conditions and whether this activity feeds back and inhibits the further release of calcium. He will also study whether this stress-activated internal calcium release plays a role in apoptosis, or programmed cell death.

In addition, Dr. Glazner will study the role of a recently discovered neurotrophic factor, a protein that facilitates the growth or repair of nerve cells. His studies have found that this factor activates NF-kappaB, and he will continue to investigate it to determine if it works through the feedback pathway.

Understanding how this feedback mechanism works is important clinically. For example, animal models of familial onset Alzheimer’s demonstrate increased release of calcium in their cells, but decreased NF-kappaB. In cardiac disease patients, as well, calcium release is elevated and NF-kappaB is low. In stroke, cells experience a delayed death response for weeks after the initial insult. Further studies of how these feedback pathways work in models of pathenogenisis may point the way toward treatment and preventative measures.

Student Supervision:

Post-Doctoral

2002-2004 Xiao Yan Mao, Pharmacology and Therapeutics, Medicine “Unique proteolysis regulated by ER calcium release’
Currently Laboratory Manager, UM

Doctorate

2004-2008 Dr. Kelly Olson, Ph. D., Pharmacology and Therapeutics, Examination of in vitro pathology in an animal model of Alzheimer’s Disease.
Graduated with Ph.D. 2008

2006-Present Jason Schapansky, Ph. D., Candidate, Pharmacology and Therapeutics, Regulation of neuronal calcium by neuregulin

2005-Present Dr. Darrel Smith, DVM., Ph. D., Candidate Pharmacology and Therapeutics, The role of NF-kappa B in sensory neuron function

Masters

2006-Present Nancy Young, Ph. D., Pharmacology and Therapeutics, The role of NF-kappaB in diabetic sensory neuropathy II. Service on Graduate Student Committees

Doctorate

2004-present Waylon Hunt, Ph. D., Pharmacology and Therapeutics (Committee Member)

2002 – Present Christine Zamzow, Ph.D., Pharmacology and Therapeutics (Committee Member)

2007-Present Solmaz Nafez, PhD., Pharmacology and Therapeutics (Committee Member)

For more information, contact:

Dr. Gordon Glazner
gglazner@sbrc.ca

Journal Articles

Salins P, He Y, Olson K, Glazner G, Kashour T, Amara F. (2008) TGF-beta1 is increased in a transgenic mouse model of familial Alzheimer’s disease and causes neuronal apoptosis. Neurosci Lett. 430:81-6

[My paper]V Brussee, Gf Guo, Yy Dong, C Cheng, Ja Martinez, D Smith, Gw Glazner, P Fernyhough, Dw Zochodne (2008) Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model. Diabetes 18332094

Schapansky, J., Olson, K., Van Der Ploeg, R., and Glazner, GW (2007) NF-kB activated by ER calcium release inhibits Ab-mediated expression of CHOP protein; Enhancement by AD-linked mutant presenilin 1 Exp. Neurol. (Corresponding Author)

Fernyhough P, Smith DR, Schapansky J, Van Der Ploeg R, Gardiner NJ, Tweed CW, Kontos A, Freeman L, Purves-Tyson TD, Glazner GW. (2005) Activation of nuclear factor-kappaB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons. J Neurosci. 16;25(7):1682-90. (corresponding author)

Glazner, GW. and Fernyhough, P (2002) Neuronal survival in the balance: Are ER membrane proteins the fulcrum? Cell Calcium 32:421-33. (corresponding author)

Solovyova N, Fernyhough P, Glazner G, and Verkhratsky A. (2002) Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones. Cell Calcium.32:49-52.

Glazner, GW, Camandola, S, Geiger, JD and Mattson, MP (2001) Endoplasmic reticulum D-myo-inositol 1, 4, 5-trisphosphate-sensitive stores regulate nuclear factor-kB binding activity in a calcium-independent manner. J. Biol. Chem. 276:22461-22467.

Glazner, GW, Camandola, S, and Mattson, MP (2000) Nuclear factor-kappa B mediates the cell survival-promoting action of activity-dependent neurotrophic factor peptide 9. J. Neurochem. 75: 101-108. (Corresponding Author)

Glazner, GW, Chan, SL, Lu, C, and Mattson, MP. (2000) Caspase-mediated degradation of AMPA receptor subunits: A mechanism for preventing excitotoxic necrosis and ensuring apoptosis. J. Neurosci. 20: 3641-3649.

Glazner, GW, Fu W, and Mattson, MP. (2000) Differential effects of BDNF, ADNF-9, and TNF-a on regulation of NMDA receptor subunits and NMDA-mediated excitotoxicity. Exp. Neurol. 161: 442-452.

Guo, Q., Sebastian, L., Sopher, B., Miller, MW, Glazner, GW, Ware, C. B., Martin, G. M., and Mattson, M. P. (1999). Neurotrophic factors (ADNF and bFGF) interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Nat. Acad. Sci. 96: 4125-4130.

Glazner, GW, Boland, A., Dress, A., Brenneman, D. E., Gozes, I. and Mattson, M. P. (1999) Activity-dependent neurotrophic factor peptide (ADNF-9) protects neurons against oxidative stress-induced death. J. Neurochem 73: 2341-7.

Glazner, GW, Gressens, P., Lee, S., Gibney, G., Gozes, I., Gozes, Y., Brenneman, D.E., and Hill, J. M. (1999) Activity Dependent Neurotrophic Factor: A potent regulator of embryonic growth. Anat. Embryol. 200: 65-71.

Bassan, M., Zamostiano, R., Davidson, A., Perl, O., Bassari, H., Blat, C., Gibney, G., Glazner, GW, G., Brenneman, D. E., and Gozes, I. (1999) Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J. Neurochem., 72: 1283-1293.

Glazner, GW, Mu X., and Springer J. E. (1998) Localization of glial cell line-derived neurotrophic factor (GDNF) receptor alpha and c-Ret mRNA in the rat central nervous system. J. Comp. Neurol. 391: 42-49.

Dibbern, D. A., Glazner, G. W., Brenneman, D. E., and Hill, J. M. (1997) HIV Envelope Protein GP120 Inhibits Embryonic Growth: Prevention by Vasoactive Intestinal Peptide. J. Clin. Inves. 99: 2837-41.

Glazner, G. W., Yadiv, K., Coven, E., Brenneman, D. E., and Nelson, P. G. (1997) Acetylcholine Increases Prothrombin Activity and Gene Expression in cultured Muscle. Dev. Brain Research 99: 148-154.

Hill, J. M., McCune, S. K., Alvero, R. J., Glazner, G. W., Henins, K. A., Stanziale, S., Keimowitz, J. and Brenneman, D. E. (1996) Maternal Vasoactive Intestinal Peptide and the Regulation of Embryonic Growth in the rodent. J. Clin. Inves. 97: 202-208.

Brenneman, D. E., Hill, J. M., Glazner, G. W., Gozes, I., and Phillips, T. W. (1995) Interleukin-1 alpha and Vasoactive Intestinal Peptide: Enigmatic Regulation of euronal Survival. Int. J. Dev. Neuroscience. 13: 187-200.

Glazner, G. W. and Ishii, D. N. (1995) Insulin-like growth factor gene expression in rat muscle during reinnervation. Muscle & Nerve 18:1433-42.

Ishii, D. N., Glazner, G. W. and Pu, S. F. (1994) Role of insulin-like growth factors in peripheral nerve regeneration. Pharmaco.Ther. 62:125-144.

Glazner, G. W., Morrison, A. E., and Ishii, D. N. (1994) Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration. Mol. Brain Res. 25:265-272.

Glazner, G. W., Lupien, S. Miller, J. A. and Ishii, D. N. (1993) Insulin-like growth factor increases the rate of sciatic nerve regeneration in rats. Neuroscience 54: 791-797.

Kulkosky, P. J., Doyle, J. S., Cook, V. I., Glazner, G. W., and Foderaro, M. A. (1989) Vasoactive intestinal peptide: behavioral effects in the rat and hamster. Pharmacol. Biochem. Behav. 34(2): 387-93

Kulkosky, P. J., Glazner, G. W., Moore, H. D., and Woods, S. C (1988) Neuropeptide Y: behavioral effects in the golden hamster. Peptides 9: 1389-93.

Glazner, G. W., Cannon, R. L., and Kulkosky, P. J. (1988) Effects of bombesin on behaviors associated with ethanol satiation and blood ethanol levels. Alcohol 5: 325-330.

Kulkosky, P. J., Foderaro, M. A., Glazner, G. W., Niichel, V. I., and Schnur, P. (1988) Bombesin-induced grooming in the golden hamster. Behav. Brain Res. 29:173-7.

Kulkosky, P. J., and Glazner, G. W. (1988) Dose-additive inhibition of intake of ethanol by cholecystokinin and bombesin. Alcohol Clin. Exp. Res. 12: 277-81.

Kulkosky, P. J., Sanchez, M. R., and Glazner, G. W. (1987) Cholecystokinin Octapeptide: Effect on the ethogram of ethanol consumption and blood ethanol levels in the rat. Physio. Psych. 14(1&2): 23-30.

Kulkosky, P. J., Sanchez, M. R., Chiu, N. and Glazner, G. W. (1987) Characteristics of bombesin-induced inhibition of intake of ethanol. Neuropharmacology 26:1211-16.

Book Chapters and Reviews

Keller, J. N. and Glazner, G. W. (2001) “Mitochondrial Oxidative Stress and Metabolic Alterations in neurodegenerative disorders” in: Interorganellar Signaling in Age-Related Disease (M. P. Mattson, Ed) 205-237. Elsevier Science Press, Amsterdam.

Glazner, G. W. (1999) “Mitochondrial mutations and neurodegenerative diseases” In: Genetic Aberrancies and Neurodegenerative Disorders Advances in Gerontology, (M. P. Mattson, Ed.) Vol. 3: 313-354. JAI Press, Stamford CT.

Hill, J. M., Glazner, G. W., Lee, S. J., Gozes, I., Gressens, P., and Brenneman, D. E. (1999) Vasoactive intestinal peptide regulates embryonic growth through the action of activity dependent neurotrophic factor Ann. N.Y. Acad. Sci., 897: 92-100.

Gozes, I, Bassan, M., Zamostiono, R., Pinhasov, A., Davidson, A., Giladi, E., Glazner, G. W., and Brenneman, D. E. (1999) A novel signaling molecule for neuropeptide action: activity- dependent neuroprotective protein. Ann. N.Y. Acad. Sci., 897:125-35.

Brenneman, D. E., Glazner, G. W., Hill, J. M., Hauser, J., Davidson, A., and Gozes, I. (1998) VIP neurotrophism in the central nervous system: multiple effectors and identification of a femtomolar-acting neuroprotective peptide. Ann. N.Y. Acad. Sci. 865: 207-212.

Journal Articles submitted or in preparation

Schapansky, J., M. Morissette, and Gordon W. Glazner. 2007. Neuroregulin b1

enhances peak glutamate-induced intracellular calcium levels through endoplasmmic reticulum calcium release in cultured hippocampal neurons. European Journal of Neuroscience. (Submitted) Corresponding Author.

Salins P, He Y, Olson K, Pylypas S, Burton T, Dibrov A, Glazner G, Kashour T, Amara F, “Reduced Expression of the Adaptor Protein FE65 by Amyloid Beta Contributes to Neurodegeneration in TgCRND8 Mice and Alzheimer Brain”, Submitted to Brain Research

Smith D, Tweed C, Fernyhough P, Schapansky J, Glazner GW. Inhibition of TNFa increases early axonal regeneration and reduces NF-kB DNA binding activity following sciatic nerve injury

Olson, K, J. Schapansky, P. Salins, Y. He, F. Amara, and Gordon W. Glazner. 2007. Cultured cortical neurons from embryonic TgCRND8 mice display. Ab-mediated Pathology and increased cell death”. In Preparation.

Invited lectures

“Endoplasmic Reticulum control of proteolysis in neurons” IBRO conference, Prague, Czech Rep. (2003)

“The ER microproteome: Integrated signaling of multiple proteins” RIKEN Institute, Tokyo, Japan (2003).

“Role of ER-stimulated NF-kB in cytokine-stimulated HIV replication” San Raphael Institute, Milan, Italy (2002).

“NFkB regulates adult sensory neuron survival through cytokine activation of intracellular calcium stores” University of Edinburgh, Edinburgh, UK (2001)

“A novel mechanism of NFkB regulation: Implications for central and peripheral disease” Queen Mary and Westfield College, London UK (2001).

“The NF-kB/ Endoplasmic Reticulum Survival Axis: Implications for Alzheimer’s Disease and Beyond” National Institute on Aging, NIH, Baltimore, MD (2000).

“Calcium and Apoptosis: Tweaking Old Paradigms” Departments of Pharmacology and Physiology, University of North Dakota, Grand Forks, ND (2000).

“Synaptic and molecular regulation of apoptosis: Implications for Alzheimer’s and other neurodegenerative disorders” Mosbacher Kolloquium: Molecular Mechanisms in Nervous System Disorders. Mosbach, Germany (1999)

“Activity-dependent regulation of NF-kB by a novel neurotrophic peptide” Queen Mary and Westfield College, London, UK (1998)

Abstracts and Presentations

Olson KL, Schapansky J, Salins P, Yang He, Amara F, Glazner GW, “Cultured Neurons from Embryonic TgCRND8 Mice Display Cell Death, Increased Amyloid Beta Production, and Aberrant Calcium Regulation”, International Conference on Alzheimer’s and Parkinson’s Disease, Salzburg, Austria, 2007

N. Young, E. Zherebitskaya, P. Fernyhough, G. W. Glazner, NF-kappaB activity in cultured normal and streptozotocin-diabetic dorsal root ganglia neurons regulates axonal growth and morphology Society for Neuroscience Conference, San Diego, CA, 2007

Smith, D., Tweed, CW., Fernyhough, PF., and Glazner, GW., Role of TNFa-induced activation of NF-kB in morphological and functional axon regeneration in axotomized adult sensory neurons. Peripheral Nerve Society, Snowbird, Utah 2007

Kathryn Collister, Gary Odero, Kensaki oikawa, Gordon Glazner, and Benedict Albensi “Spatial memory formation and hippocampal function are influenced by background strain but not gender in the TgCRND8 mouse model of Alzheimer’s Disease. Society for Neuroscience Conference, San Diego, CA, 2007

Olson KL, Schapansky J, Salins P, Yang He, Amara F, and Glazner GW “Cultured Neurons from Embryonic TgCRND8 Mice Display Increased Cell Death, Increased Amyloid Beta Production, and Aberrant Calcium Regulation”, International Conference on Alzheimer’s Disease, Madrid, Spain, 2006

Kelly L. Olson, Jason S. Schapansky, Pradeep Salins, Yang He, Francis M. Amara, and Gordon W. Glazner “Cultured cortical neurons from embryonic TgCRND8 Mice display aberrant calcium regulation and increased cell death”. Society for Neuroscience Conference, Atlanta GA, 2006.

Paul Fernyhough, Darrel Smith, Jason Schapansky, and Gordon Glazner “NF-kB and CREB DNA binding activities are aberrant in sensory ganglia and peripheral nerve of streptozotocin type diabetic rats” Society for Neuroscience Conference, Atlanta GA, 2006.

Christopher Tweed, Darrell Smith, Jason Schapansky, Paul Fernyhough, and Gordon Glazner “Inhibition of TNFa increases early axonal regeneration and reduces NF-kB DNA binding activity in sciatic nerves following nerve injury”. Society for Neuroscience Conference, Atlanta GA, 2006.

Kensuke Oikawa, Gary Odero, Darrell Smith, Gordon Glazner, and Benedict Albensi “Impairment of Synaptic Plasticity in Streptozotocin-Diabetic Rats” Society for Neuroscience Conference, Atlanta GA, 2006.

Jason Schapansky and Gordon Glazner “Neuregulin- enhances glutamate-mediated calcium influx in rat hippocampal neuronal cultures” Society for Neuroscience Conference, Atlanta GA, 2006.

Darrel Smith ,, Randall Van Der Ploeg, Jason Schapansky, Phillip Gardiner, and Gordon.Glazner “Loss of electrochemical activity Regulates Axotomy-Induced NF-B Activation In Adult Rat Sensory Neurons”. Society for Neuroscience Conference, Atlanta GA, 2006.

Zuocheng Wang, Darrell Smith, Gordon Glazner, Nigel Calcutt, Andrew Mizisin and Paul Fernyhough “Abnormal mitochondrial respiration is normalized by insulin treatment that does not affect hyperglycemia in sensory neurons in diabetic rats”. Society for Neuroscience Conference, Atlanta GA, 2006.

Tweed, CW., Glazner, GW., and Fernyhough, PF., Role of TNFa-induced activation of NF-kB in axon regeneration in axotomized adult sensory neurons. Society for Neuroscience Conference, Washington, DC 2005

Olson, KL., Schapansky, JS., Van Der Ploeg R., Glazner, GW., The role of

hyperglycemia/hyperinsulinemia on neuronal survival in TgCRND8 mice. Society for Neuroscience Conference, Washington, DC 2005

Glazner, G. W. and Buchting, A. NF-kB binding activity reduces calcium release from intracellular stores by regulating endoplasmic reticulum-resident IP3-mediated calcium channels. Society for Neuroscience Conference, San Diego, CA 2004

Smith, D., and Glazner, G. W. NFkB activation in dorsal root ganglia following nerve injury is regulated by electrical signalling. Society for Neuroscience Conference, San Diego, CA 2004

Schapansky, J., and Glazner, G. W. Neuregulin b-1 regulates intercellular calcium influx in cultured rat cortical neurons via NMDA receptors. Society for Neuroscience Conference, San Diego, CA 2004

Olson, K, Binns, K., Bao, X-Y, Schapansky, J., Van Der Ploeg, R. Pawson, T., and Glazner, G. W. Release of calcium from rat brain microsomes regulates a novel proteolytic activity. Society for Neuroscience Conference, San Diego, CA 2004

Wover R. M. A., Purves T., Fernyhough P.T., Glazner, G. W. “NF-kB activation is a component in signaling pathway required for maintenance of adult sensory neurons”. NF-kB: From bench to Bedside. Keystone Symposia, Keystone CO, 2002

Glazner, G. W., Camandola, S., Geiger, J. D., and Mattson, M. P. “Endoplasmic reticulum D-myo-inositol 1, 4, 5-trisphosphate-sensitive stores regulate nuclear factor-kB binding activity in a calcium-independent manner. International NF-kB Symposium: NF-kB: Regulation, Gene Expression and Disease, Gent, Belgium, 2001

Camandola, S., Glazner, G. W., and Mattson, M. P. “Regulation of IP3 calcium channels by nuclear factor kappa B” International NF-kB Symposium: NF-kB: Regulation, Gene Expression and Disease, Gent, Belgium, 2001

Glazner, G. W. and Fernyhough, P. “Activation of NFKB regulates the survival of adult sensory neurones” International NF-kB Symposium: NF-kB: Regulation, Gene Expression and Disease, Gent, Belgium, 2001

Glazner, G. W., Camandola, S., Geiger, J. D., and Mattson, M. P. “Novel mechanisms of NF-kB regulation: Implication for Alzheimer’s disease and beyond” Canadian Symposium on Neuroimmune Biology, 2000, Winnipeg, MB.

Glazner, G. W., Camandola, S., Geiger, J. D., and Mattson, M. P. “Reciprocal regulation of NF-kB binding activity and endoplasmic reticulum IP3 calcium channel activation”. Keystone Conference on NF-kB Regulation and Function: From Basic Research to Drug Development, 2000, Lake Tahoe, CA.

Glazner, G. W., Kruman, I. I., Nath, A., Geiger, J. D., and Mattson, M. P. “HIV protein TAT activates apoptotic cascades in hippocampal neurons: Protection by ADNF-9 and NF-kB activation” HIV and the Nervous System, 1999, Washington D.C.

Glazner, G. W., Chan, S. L., and Mattson, M. P. AMPA subunit protein levels and

glutamate sensitivity are mediated by caspases. Soc. Neurosci. Abs. 1999, Miami, FL.

Glazner, G. W., Boland, A., Camandola, S., Dress, A., Brenneman, D. E., Gozes, I., and Mattson, M. P. “Mechanisms of ADNF peptide protection against oxidative and excitotoxic neuronal death” Ann. Am. Soc. Neurochem. Abs. 1999, New Orleans, LA.

Glazner, G. W., A. Boland, A.. Dress, Brenneman, D. E., Gozes, I., and Mattson, M. P. “ADNF-9 protects neurons against oxidative stress-induced death by activation of the transcription factor NF-kB”. Soc. Neurosci. Abs. 1998, Los Angeles, CA.

Gibney, G., Castellon, R., Glazner, G. W., Gozes, I., and Brenneman, D. E. “Neutralizing antiserum to rat activity-dependent neurotrophic factor (ADNF-I) detects a human homologue” Soc. Neurosci. Abs 1997, New Orleans, LA.

Hill, J. M., Chang, S., Glowa, J. R., Gressens, P., Abebe, D. T., Libel, C., Dibbern, D., Lee, S. J., Gibney, G., Gozes, I., Glazner, G. W., and Brenneman, D. E. “Learning impairment in adult mice produced by early embryonic administration of antisera to activity-dependent neurotrophic factor (ADNF)” Soc. Neurosci. Abs 1997, New Orleans, LA.

Gozes, I., Bassan, M., Zamostiano, R., Davidson, A., Perl, O., Bassan, H., Blat, C., Gibney, G., Glazner, G. W., and Brenneman, D. E. “The cDNA structure of a novel femtomolar-acting neuroprotective factor III (ADNF III)” Soc. Neurosci. Abs 1997, New Orleans, LA.

Glazner, G. W., Brenneman, D. E., Gozes, I., and Mattson, M. P. ” A 9 amino acid peptide fragment of activity-dependent neurotrophic factor (ADNF) protects neurons from FeSO4-induced oxidative toxicity” Soc. Neurosci. Abs 1997, New Orleans, LA.

S.J. Servoss, G.W. Glazner, S.J. Lee, G. Gibney, J.Y. Wu, D.E. Brenneman, and J.M. Hill “Mechanism of Vasoactive Intestinal Peptide-Stimulated Embryonic Growth: IGF-1, Cyclins, and Fos.” Soc. Neurosci. Abs 1996, Washington D.C.

J.M. Hill, P. Gressens, G.W. Glazner, and D.E. Brenneman “Floor plate neuroepithelium has binding sites for growth regulator vasoactive intestinal peptide.” Soc. Neurosci. Abs 1996, Washington D.C.

G.W. Glazner, P. Gressens, I. Gozes, D.E. Brenneman, and J.M. Hill “Regulation of Embryonic Growth by the Neuropeptide, Vasoactive Intestinal Peptide” NIH Research Festival ‘95 1995, Bethesda, MD.

D.E. Brenneman, G.W. Glazner, M. Fridkin, Gozes, I., Gressens, P., And Hill, J. “Neuroendocrine Control of Embryogenesis by a Neuropeptide” 7th Meeting European Neuroendocrine Association, 1995, Tel Aviv, Israel.

J. Y. Wu*, G. W. Glazner and R. A. Alvero “Vasoactive Intestinal Peptide Immunoreactivity and mRNA is Present in a Human Astrocytoma Cell Line”. Soc. Neurosci. Abs. 21: 1995, San Diego, CA.

G. W. Glazner, J. Y. Wu, P. Gressens, I. Gozes, D. E. Brenneman and J. M. Hill “Vasoactive Intestinal Peptide Stimulation of Embryonic Growth in Cultured E9 Mice is Partially Mediated through Activity-Dependent Neurotrophic Factor and Cyclin A” Soc. Neurosci. Abs. 21: 1995, San Diego, CA

Glazner, G.W., Brenneman, D. E., Jain, N. and Hill, J. M. “Differential Gene Expression of Trophic Factors between Embryo and Extraembryonic Membranes in Cultured E9 Mice” Soc. Neurosci. Abs. 20: 1994, Miami, FL.

Glazner, G.W. and Ishii, D.N. ” Kinetics of IGF mRNA Changes in rat nerve and muscle during IGF-dependent nerve regeneration” 15th Ann. Winter Neuropeptide Conference, February 1994, Breckenridge, CO.

Glazner, G.W., Wright, W.G., and Ishii, D.N. ” Kinetics of IGF mRNA Changes in rat nerve and muscle during IGF-dependent nerve regeneration” Soc. Neurosci. Abs. 19: 253 (1993).

Glazner, G.W., Lupien, S., Miller, J.A., and Ishii, D.N. “Insulin-like growth factors regulate the rate of sciatic nerve regeneration” Soc. Neurosci. Abs. 18: 427 (1992).

Ishii, D.N., and Glazner, G.W. “Relationship of IGF-I and IGF-II gene expression to development and regeneration of synapses in the rat” In: 2nd International Symposium on Insulin-Like Growth Factors/Somatomedins January 1991, San Francisco, p. 173.

Glazner, G.W., Niedzwiecki, D.M. and Ishii, D.N. “Relationship of insulin-like growth factor-I mRNA content in muscle to regeneration of neuromuscular synapses” Soc. Neurosci. Abs. 16: 340 (1990).

Glazner, G.W., and Ishii, D.N. “Relationship of insulin-like growth factor I mRNA content to synaptogenesis in rat muscle” Soc. Neurosci. Abs. 15: 1353 (1989).

Glazner, G.W., and Ishii, D.N. “Effects of insulin, NGF and IGFs on neurite outgrowth in cultured embryonic rat spinal cord neurons” 9th Ann. Rocky Mount. Region. Biochem. Conf. (1988).

Glazner, G.W., and Ishii, D.N. “Insulin, insulin-like growth factor-I and nerve growth factor stimulate neurite formation in rat spinal cord cultures” Soc. Neurosci. Abs. 14: 688 (1988).

Glazner, G.W., and Kulkosky, P.J. “Bombesin: Effect on the ethogram of ethanol satiation and blood ethanol levels” Soc. Neurosci. Abs. 12: (1986).

Kulkosky, P.J., Sanchez, M.R., and Glazner, G.W. “Cholecystokinin Octapeptide: Effect on the ethogram of ethanol consumption and blood ethanol levels in the rat” Soc. Neurosci. Abs 11: (1985).


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Health Administration Award; Doctors Manitoba, 2011.

Teacher of the Year Award for Graduate Students, Dept. of Medical Microbiology, 2007-08.

Innovation Award; University of Manitoba, March 2006.

Distinguished Microbiologist Award; Canadian College of Microbiologists, April 2005.

Most Outstanding Teacher Award; For Med I Class of 1996-1997, from the Manitoba Medical Students’ Association.

Most Outstanding Teacher Award; For Med I Class of 1995-1996, from the Manitoba Medical Students’ Association.

New Funding:

October 2007: Canadian Institutes of Health Research (CIHR) $120,000p.a. Operating grant: Impaired calcium homeostasis and mitochondrial dysfunction in diabetic sensory neuropathy.PI: Fernyhough, P. (Co-applicant: Glazner, Gordon W.; Univ of Manitoba) 2007 – 2012

Ongoing Funding:

2006 – 2008 Canadian Diabetes Association (CDA) $ 75,000 p.a.Operating grant: Role of transcription factor, NF-B, in symmetrical sensory polyneuropathy in diabetes. PI: Fernyhough, P (Co-applicant: Glazner, G.W.; Univ of Manitoba)

2007 – 2008 Alzheimer’s Society of Canada 75,000 p.a. Examination of ER calcium dyshomeostasis in a murine model of AD: Evaluation of therapeutic intervention using an ER calcium channel inhibitor. PI: Glazner, G.

New Awards to Dr. Glazner’s trainees:

Graduate Student Jason Schapansky (Supervisor: G Glazner)

CIHR Doctoral Award (3 years) The role of neuregulin in intracellular calcium release in AD (08/01/2009 – 08/31/2011)

MHRC Studentship – declined renewal (accepted CIHR award)

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