ICS Menu
-
Follow Us...
Dr. Davinder S. Jassal
– Cardiovascular Imaging
Dr. Davinder S. Jassal
Principal Investigator, Cardiovascular Imaging
Institute of Cardiovascular Sciences
Research Focus
Dr. Jassal’s research focuses on the complementary use of multimodality cardiovascular imaging in the noninvasive assessment of heart failure syndromes. Using a combination of echocardiography (ultrasound of the heart), cardiac CT (computed tomography) and CMR (cardiac MRI), the Cardiovascular Imaging Laboratory at St. Boniface General Hospital and Research Centre is dedicated to translational research focusing on four heart failure models:
1. Trastuzumab (Herceptin) and Heart failure: A Tale of Two Cities
Cardiovascular disease and breast cancer are major public health concerns in Canada. The two diseases are intricately involved as treatment of one disease may lead to detrimental effects in the other. Although the current combination of surgical resection, radiotherapy, and chemotherapy may lead to remission in breast cancer patients, the administration of chemotherapeutic based agents, in particular Doxorubicin, are associated with an increased risk of cardiotoxicity. The introduction of novel monoclonal antibodies in breast cancer therapy which target growth factor receptors further compounds this issue of drug induced cardiac dysfunction.
Trastuzumab (Herceptin), a humanized monoclonal antibody against the extracellular domain of the HER-2 protein, is used in both the adjuvant and metastatic settings of breast cancer. Despite its clear therapeutic benefits, cardiotoxicity is a major concern, especially when trastuzumab is used in combination with anthracyclines. Although clinical trials have demonstrated that the risk of developing LV systolic dysfunction after receiving trastuzumab is up to 10%, recent studies have shown an even higher risk of nearly 1 in 4 women developing this drug induced cardiomyopathy. An understanding of the potential mechanisms for the deleterious cardiac effects of HER-2 blockade may be beneficial in improving breast cancer therapy.
2. Metabolic Syndrome and Heart Failure
The metabolic syndrome is an increasing public health concern in Canada due to the growing incidence and prevalence of obesity nationwide. It is estimated that 1 in 4 Canadians will be afflicted with the metabolic syndrome by 2010. The metabolic syndrome is characterized by a cluster of risk factors including impaired glucose tolerance, hypertension, dyslipidemia, and obesity. Individuals afflicted with the metabolic syndrome are at an increased risk of developing premature cardiovascular disease and diabetes. The development of safe and inexpensive ways of preventing and treating the metabolic syndrome is fundamental in reducing the increasing diabetic and cardiovascular complications of this disease. We are exploring whether nutraceuticals and pharmaceuticals can prevent the adverse diabetic and cardiovascular effects of the metabolic syndrome.
3. Marathon Running and Heart Failure
Can too much exercise be detrimental to your health? Physical fitness has been shown to be an independent, long-term predictor of reduced morbidity and mortality from cardiovascular causes. Although the cardiovascular benefits of moderate exercise are well established, the cardiovascular effects of prolonged exertion, including marathon running, are less clear. Even though the risk of sudden death associated with participation in marathons is small, participation in such events is consistently associated with biochemical evidence of heart damage and dysfunction. Using cardiac biomarkers, echocardiography, cardiac CT and cardiac MRI, Dr. Jassal is evaluating the effects of marathon running on cardiac function through our participation with the 2006-2011 Manitoba Marathons.
4. CHIRP (Cardiac hemodynamic imaging and remodeling in pregnancy)
The progression of pregnancy causes multiple physiologic changes in the female cardiovascular system. Such changes include enlargement of all four cardiac chambers, increased left ventricular wall thickness, mild valvular regurgitation, and an increase in both plasma volume and cardiac output by 40%.
Structural and functional changes that develop during pregnancy have previously been investigated by numerous methods, and echocardiography is currently the standard modality. Due to the inherent limitations of echocardiography, we are investigating the use of cardiac MRI to study the changes in cardiac physiology during pregnancy.
The objective of the CHIRP Study is to determine the range of normal structural and functional changes of the heart during a healthy pregnancy by employing both cardiac echocardiography and MRI.
Why is this work important?
Diagnostic medical imaging has undergone a dramatic evolution over the past decade, owing to rapid technological advancement and innovative clinical applications. Today’s diagnostic imaging technologies, in particular echocardiography and cardiac MRI, are rapidly being adopted in Canada as new tools for understanding mechanisms of disease including Herceptin induced cardiomyopathy, obstructive sleep apnea and the metabolic syndrome.
Although Herceptin has demonstrated considerable therapeutic benefits in decreasing the rates of disease recurrence and death in the setting of breast cancer, it is associated with a 5-10% risk of cardiotoxicity. Early detection of cardiac dysfunction using echocardiography and cardiac MRI may allow one to adjust treatment with Herceptin prior to the development of irreversible heart failure. With the increasing epidemic of obesity in Canada, the prevalence of OSA will continue to rise. A composite of mechanisms including mechanical, neurohormonal, inflammatory, endothelial and oxidative stress are involved in the increasing cardiovascular disturbances observed in OSA patients. The anticipated outcome of the current research proposal is that Dr. Jassal will demonstrate for the first time that CPAP will favorably improve biventricular remodeling in a heterogeneous population of OSA patients, as assessed noninvasively by echocardiography, cardiac MRI, and biomarkers over a one year followup.
There is increasing evidence that obesity and the metabolic syndrome plays a major role in cardiovascular disease. By studying the effects of a high fat diet on adverse cardiac remodeling, and understanding the various mechanisms involved, the insights gained will help with the development of novel dietary and pharmaceutical strategies to limit heart failure and its associated morbidity and mortality.
What techniques and equipment are used in this laboratory?
Dr. Jassal’s small animal cardiovascular imaging laboratory provides expertise in murine echocardiography. A dedicated GE Vivid 7 echocardiography machine with probes for small animal imaging (13 MHz) is housed in the animal facility at St. Boniface Research Centre. Five dedicated postprocessing work stations are located in Dr. Jassal’s laboratory, Rm 4010 for analysis of the images using standard M-Mode, 2D echocardiography, color Doppler and Tissue Doppler imaging. The work stations are also used for postprocessing of cardiac MRI images.
To delineate mechanistic pathways involved in the cardiovascular remodeling assessed by murine echocardiography, the lab is also equipped with histological and immunohistochemistry techniques.
About Dr. Davinder S. Jassal
Dr. Jassal was born in Thompson, Manitoba, obtained an International Baccalaureate Degree at Sisler High School in Winnipeg, and graduated from the University of Manitoba with an MD in 1998. He completed a residency in Internal Medicine at the University of Manitoba from 1998-2001 and a residency in Cardiology at Dalhousie University in Halifax, Nova Scotia, Canada. Subsequently, he completed a clinical and research fellowship in Cardiac Imaging specializing in echocardiography, computed tomography, and MRI at Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Dr. Jassal recently rejoined the Cardiac Sciences division as an Academic Clinician Scientist, where half of his time is devoted to patient care in CCU and cardiac imaging and the other half devoted to translational research. He is currently Assistant Professor of Cardiology and Radiology, Affiliated Scientist of the Institute of Biodiagnostics at National Research Council of Canada, Principal Investigator of the Cardiovascular Imaging Laboratory as a member of the Institute of Cardiovascular Sciences, and holds the F.W. DuVal Clinical Research Professorship.
For more information, please contact:
Dr. Davinder S. Jassal
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. 204.237.2599
Lab Office. 204.235.3056
Hospital Office. 204.237.2023
Fax. 204.233.2157
Email. djassal@sbgh.mb.ca
Sheena Bohonis
Research Technician
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. 204.237.2599, 204.235.3741
Fax. 204.233.6723
Email. sbohonis@sbrc.ca
In Detail
Insights into Chemotherapy Induced Cardiomyopathy
In women who have been diagnosed with HER-2 positive breast cancer, studies have shown that when treated with a drug called Herceptin (Trastuzumab), the rate of recurrence and death decreases substantially. Despite these positive effects, Herceptin also increases the change of developing heart failure in 10% of women. At the basic science level, Dr. Jassal has evaluated the use of Tissue Doppler imaging in murine echocardiography to predict a decrease in overall left ventricular ejection fraction and apoptosis (programmed cell death) in a chemotherapy induced model of heart failure in mice. Translating this to the clinical bedside, his research will focus on the early detection of heart failure using cardiac imaging including echocardiography and MRI in patients with breast cancer, such that alterations in treatment with Herceptin can be made prior to irreversible heart damage.
2011
1. Fallah-Rad N, Walker JR, Wassef A, Lytwyn M, Bohonis S, Fang T, Tian G, Kirkpatrick ID, Singal PK, Krahn M, Grenier D, Jassal DS. The utility of cardiac biomarkers, tissue velocit and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor-II positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol 2011; 57(22): 2263-70.
2. Jiminez SK, Jassal DS, Kardami E, Cattini PA. Protection by endogenous FGF-2 against isoproterenol-induced cardiac dysfunction is attenuated by cyclosporine A. Mol Cell Biochem. 2011 May 10.
3. Hussain F, Philipp R, Ducas R, Elliot J, Dzavik V, Jassal DS, Tam JW, Roberts D, Garber P, Ducas J. The ability to achieve complete revascularization is associated with in-hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic shock registry investigators. Catheter Cardiovasc Interv. 2011 May 5.
4. Walker JR, Sharma A, Lytwyn M, Bohonis S, Thliveris J, Singal PK, Jassal DS. The cardioprotective role of probucol against anthracycline and trastuzumab mediated cardiotoxicity. J Am Soc Echocardiogr. 2011 Feb 23.
5. Jiminez SK, Jassal DS, Kardami E, Cattini PA. A single bout of exercise promotes sustained left ventricular function after isoproterenol-induced injury in mice. J Physiol Sci. 2011 Apr 13.
6. Jassal DS, Bhagirath KM, Karlstedt E, Zeglinski M, Dumesnil JG, Teo KK, Tam JW, Chan KL. Evaluating the effectiveness of rosuvastatin in preventing the profession of diastolic dysfunction in aortic stenosis: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. Cardiovasc Ultrasound. 2011 Feb 7;9(1): 5.
7. Oomah S, Mousavi N, Bhullar N, Kumar K, Walker JR, Lywtyn M, Colish J, Wassef A, Kirkpatrick ID, Sharma S, Jassal DS. The role of three dimensional echocardiography in the assessment of right ventricular dysfunction after a half marathon: comparison with cardiac magnetic resonance imaging. J Am Soc Echocardiogr. 2011 Feb; 24(2): 207-13.
8. Gillingham L, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapseed and flaxseed oils modulate serum lipid and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutrit. 2011 Feb;105(3):417-27.
9. Lin HY, King S, Ding Y, Jassal DS, Simonetti O, Gervai P, McKenzie-Matwiy, E, Tomanek B, Tian H. Novel real-time PC-MRI technique for accurate single heartbeat evaluation of pulmonary-to-systemic flow ratios using an interleaved two-slice acquisition scheme. J Magn Reson Imaging. 2011.
10. Colish J, Walker JR, Elmayergi N, Lytwyn M, Fang T, Sharma S, Jassal DS. Obstructive sleep apnea: Effects of continuous positive airway pressure on cardiac remodeling as assessed by transthoracic echocardiography and cardiac MRI. J Am Soc Echocardiogr. 2011.
2010
1. Garber PJ, Hussain F, Koenig JK, Maycher B, Jassal DS. Multimodality imaging of a coronary artery fistula after septal myomectomy in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2010. In press.
2. Lytwyn M, Fallah-Rad N, Walker JR, Bohonis S, Hussain F, Barac I, Jassal DS. The utility of dobutamine stress echocardiography for the diagnosis of coronary artery disease in the HIV population. Echocardiography. 2010. In press.
3. Han CS, Bohonis S, Walker JR, Vo M, Hussain F, Pascoe E, Jassal DS. An unusual presentation of left ventricular free wall rupture. Can J Cardiol. 2010. In press.
4. Walker JR, Lee J, Strzelczyk J, Jassal DS, Soni A. Congenital aorta to right atrial fistula. Cardiol J. 2010. In press.
5. Mousavi N, Czarnecki A, Ahmadie R, Fang T, Kumar K, Lytwyn M, Kumar A, Jassal DS. The utility of Tissue Doppler imaging for the noninvasive determination of left ventricular filling pressures in patients with septic shock. J Intensive Care Med. 2010;25(3):163-7.
6. Walker JR, Bhullar N, Fallah-Rad N, Lytwyn M, Golian M, Fang T, Summers AR, Singal PK, Barac I, Kirkpatrick ID, Jassal DS. The role of 3D echocardiography in breast cancer: comparison with 2D echocardiography, MUGA and cardiac MRI. J Clin Oncol. 2010;28(21):3429-36.
7. Ariyarajah V, Shaikh N, Garber PJ, Kirkpatrick IDC, McGregor R, Jassal DS. Cardiovascular magnetic resonance in mild to moderate clozapine-induced myocarditis: is there a role in absence of electrocardiographic and echocardiographic abnormalities? J Magn Reson Imaging. 2010;31(6):1473-6.
8. Mousavi N, Jassal DS, Moon M, Shaikh N, Soni A. Thrombus in transit. Can J Cardiol. 2010 Mar;26(3):e133.
9. Jassal DS, Bhagirath KM, Tam JW, Sochowski RA, Dumesnil JG, Giannoccaro PJ, Jue J, Pandey AS, Joyner CD, Teo KK, Chan KL. Association of bicuspid aortic valve morphology and aortic root dimensions: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. Echocardiography. 2010:27(2); 174-9.
2009
10. Ariyarajah V, Hussain F, McGregor R, Raabe M, Menkis A, Jassal DS. Progression of low-pressure to acute classic cardiac tamponade: a diagnostic dilemma in the setting of spontaneous left ventricular rupture. Am Heart Hosp J. 2009. In press.
11. Jassal DS, Moffat T, Ahmadie R, Fang T, Krahn J. Sharma S. Effect of strenuous endurance exercise on cardiac troponin T, creatinine kinase and myoglobin levels in a heterogeneous group of non-elite athletes. Int J Sports Med. 2009. In press.
12. Hildebrand AM, Bhagirath KM, Ariyarajah V, Walker JR, Houston DS, Zieroth S, Tam JW, Kirkpatrick IDC, Jassal DS. Myocardial siderosis due to hemochromatosis in an individual with hypertrophic cardiomyopathy. Can J Cardiol. 2009;25(12): e424-5.
13. Mousavi N, Kreml R, Kirkpatrick ID, Philipp R, Jassal DS. Multimodality imaging of a right saphenous vein graft pseudoaneurysm. Can J Cardiol. 2008 Dec;24(12):e106-7.
14. Mousavi N, Buksak R, Walker JR, Hussain F, Pascoe E, Kirkpatrick ID, Jassal DS. Left ventricular pseudoaneurysm: the role of multimodality imaging. Can J Cardiol. 2009 Nov;25(11):e389.
15. Nguyen T, Ahmadie R, Fang T, Lytwyn M, Francis A, Barac I, Hussain F, Zieroth S, Jassal DS. Stress echocardiography: abnormal Tissue Doppler imaging in the absence of cardiac allograft vasculopathy in heart transplant recipients. Echocardiography. 2008 Nov 7.
16. Turgeman T, Hagai Y, Huebner K, Jassal DS, Anderson J, Genina O, Nagler A, Halevy O, Pines M. Muscle fibrosis prevention and muscle performance improvement in the mdx mouse by halifuginone. Neuromuscul Disord. 2008;18(11):857-68.
17. Elmayergi N, Jassal DS, Sinha S, Seifer CM. Sudden pacemaker failure. Pacing Clin Electrophysiol. 2009;32(10):e4-6.
18. Ludke AR, Al-Shudiefat AA, Dhingra S, Jassal DS, Singal PK. A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicity. Can J Physio Pharmacol. 2009;87(10):756-63.
19. Wadhwa D, Fallah-Rad N, Grenier D, Krahn M, Fang T, Ahmadie R, Lister D, Arora RC, Barac I, Morris A, Jassal DS. Trastuzumab mediated cardiotoxicity in the setting of adjuvant chemotherapy for breast cancer: a retrospective study. Breast Can Res Treat. 2009;117(2):357-64.
20. Ducas R, Jassal DS, Kirkpatrick I, Freed D, Zieroth S, Ducas J. Dynamic compression of the left main coronary artery by the left atrium. J Thorac Imag. 2009;24(3):237-40.
21. Mousavi N, Tam J, Kirkpatrick I, Jassal DS. Interventricular septal cleft aneurysm. Can J Cardiol. 2009;25(8):e291.
22. Walker JR, Singal PK, Jassal DS. The art of healing broken hearts in breast cancer: trastuzumab and heart failure. Exp Clin Cardiology. 2009;14(3):e62-7.
23. Walker JR, Mousavi N, Horlick E, Seifer C, Jassal DS. Tricuspid valvular papillary muscle rupture with intractable hypoxia: a rare complication post MI. J Am Soc Echocardiogr. 2009;22(7):863.e1-3.
24. Walker JR, Jassal DS. Tricuspid valvular heart disease: the forgotten valve. Perspectives in Cardiology. 2009 Jun/Jul;25(4):13-6.
25. Ducas R, Jassal DS, Zieroth S, Kirkpatrick ID, Freed D. Left ventricular outflow tract obstruction by a bioprosthetic mitral valve: diagnosis by cardiac computed tomography. Journal Thorac Imaging. 2009;24(2):132-5.
26. Mooney O, Bhagirath K, Shaikh N, MacDonald K, Hussain F, Kirkpatrick ID, Pascoe E, Jassal DS. Cardioembolic source of ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2009;53(18):1729.
27. Mousavi N, Czarnecki A, Kumar K, Fallah-Rad N, Lytwyn M, Han S, Francis A, Kirkpatrick ID, Neilan TG, Sharma S, Jassal DS. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009;103(10):1467-72.
28. Jassal DS, Han SY, Hans C, Sharma A, Fang T, Ahmadie R, Lytwyn M, Walker JR, Bhalla RS, Czarnecki A, Moussa T, Singal PK. Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthraycline mediated cardiomyopathy. J Am Soc Echocardiogr. 2009;22(4):418-24.
29. Ariyarajah V, Jassal DS, Kirkpatrick I, Kwong RY. The utility of cardiovascular magnetic resonance in constrictive pericardial disease. Cardiology in Review. 2009;17(2):77-82.
30. Chow BJ, Larose E, Bilodeau S, Ellins ML, Galiwango P, Kass M, Seth T, Jassal DS, Kirkpatrick ID, Mancini GB, Mayo J, Abraham A, White J. The ‘what, when, where, who and how?’ of cardiac computed tomography in 2009: guidelines for the clinician. Can J Cardiol. 2009;25(3):135-9.
31. Kumar K, Menkis AH, Jassal DS, Arora RC. Iatrogenic acute aortic dissection in a patient with Marfan syndrome: unusual site of intimal tear. Interact Cardiovasc Thorac Surg. 2009;8:362-3.
32. Bhagirath K, Paulson K, Ahamdie R, Bhalla R, Robinson D, Jassal DS. Clinical utility of cardiac magnetic resonance imaging in Churg-Strauss syndrome: case report and review of literature. Rheum International. 2009 Feb;29(4):445-9.
33. Nkosi J, Thakrar A, Kumar K, Ahmadie R, Fang T, Lytywn M, Francis A, Kasper K, Kirkpatrick I, Jassal DS. Meningococcal serotype Y myopericarditis. Diagn Microbiol Infect Dis. 2009 Feb;63(2):223-7.
34. Thakrar A, Farag A, Lytwyn M, Fang T, Arora R, Jassal DS. Multimodality cardiac imaging for the noninvasive characterization of intracardiac neoplasms. Int J Cardiol. 2009;132(2):e74-6.
35. Ahraf F, Jassal DS, Kirkpatrick ID, Tam J. Multimodality imaging of an old organized hemopericardium. Can J Cardiol. 2010 Jan;26(1):e33-4.
36. Jassal DS, Othman RA, Ahmadie R, Fang T, Zieroth S, Fisher G, Moghadasian M. The role of Tissue Doppler imaging in the noninvasive detection of chronic rejection after heterotopic cardiac transplantation in rats. Echocardiography. 2009;26(1):37-43.
37. Nguyen T, Kumar K, Francis A, Raaebe M, Zieroth S, Jassal DS. Pseudo cardiac tamponade in the setting of excess pericardial fat. Cardiovasc Ultrasound. 2009 Jan 22;7:3.
38. Wang L, Deng J, Wang J, Xiang B, Yang T, Gruwel M, Kashour T, Tomanek B, Summer R, Freed D, Jassal DS, Guanping D, Deslauriers R, Arora R, Tian G. Superparamagnetic iron oxide does not affect viability and function of adipose-derived stem cells and superparamagnetic iron oxide-enhanced magnetic resonance imaging identifies viable cells. Magn Reson Imaging. 2009;27(1):108-19.
2008
39. Strijack B, Ariyarajah V, Jassal DS, Morris A, McGregor R. Late gadolinium enhancement cardiovascular magnetic resonance in genotyped hypertrophic cardiomyopathy with normal phenotype. J Cardiovasc Magn Reson. 2008;10(1):58.
40. Jassal DS, Tam JW, Dumesnil JG, Giannoccaro PJ, Jue J, Pandney S, Joyner CD, Teo KK, Chan KL. Clinical usefulness of Tissue Doppler imaging in patients with mild to moderate aortic stenosis: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. J Am Soc Echocardiogr. 2008;21(9):1023-7.
41. Schaffer SA, Manji RA, Kirkpatrick I, Arora R, Zieroth S, Jassal DS. Negative pressure pulmonary edema in the coronary care unit. Can J Cardiol. 2008 Sept;24(9):e58-9.
42. Cury RC, Nieman K, Butler J, Nomura CH, Ferencik M, Shapiro MD, Hoffman U, Abbara S, Jassal DS, Gold HK, Jang IK, Brady TJ. Comprehensive assessment of left ventricular function and myocardial perfusion by 64-slice MDCT in patients with acute myocardial infarction. Radiology. 2008;248(2):466-75.
43. Mousavi N, Tam JW, Maycher B, Kirkpatrick I, Jassal DS. Cover image: multimodality imaging of a cloverleaf aortic valve. J Am Coll Cardiol. 2008 Aug.
44. Mousavi N, Bhagirath K, Ariyarajah V, Fang T, Ahmadie R, Lytwyn M, Jassal DS, Seifer C. Chiari network endocarditis: an innocent bystander. Echocardiography. 2008 Jul;25(6):642-5.
45. Elmayergi N, Khadem A, Tam JW, Jassal DS. Cover image: basal inferior wall cleft of the left ventricle. J Am Coll Cardiol. 2008 Jun.
46. Jassal DS, Tam JW, Bhagirath KM, Sochowski R, Dumesnil JG, Giannoccaro PJ, Jue J, Pandney S, Joyner CD, Teo KK, Chan KL. Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. Eur Heart J. 2008;29(12):1542-7.
47. Huebner KD, Jassal DS, Halevy O, Pines M, Anderson HE. Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halifuginone. Am J Physiol Heart Circ Physiol. 2008;294(4):H1550-61.
48. Stronger LN, McGregor R, Philipp R, Tam JW, Jassal DS. Cover image: congenital absence of the pericardium. J Am Coll Cardiol. 2008 Apr.
49. Hameed AK, Gosal T, Fang T, Barac I, Zieroth S, Hussain F, Jassal DS. Clinical utility of tissue Doppler imaging in patients with acute myocardial infarction complicated by cardiogenic shock. Cardiovasc Ultrasound. 2008;6:11.
50. Othman RA, Suh M, Fisher G, Azordegan N, Riediger N, Le K, Jassal DS, Moghadasian MH. A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in rats. Am J Physiol Heart Circ Physiol. 2008;294(3):H1452-8.
51. Czarnecki A, Fang T, Lytwyn M, Pascoe E, Jassal DS. Acute severe mitral regurgitation: consideration of papillary muscle architecture. Cardiovasc Ultrasound. 2008;6(1):5.
52. Fallah-Rad N, Lytwyn M, Fang T, Kirkpatrick I, Jassal DS. Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathy. J Cardiovasc Magn Reson. 2008;10(1):5.
53. Jassal DS, Thakrar A, Schaffer SA, Fang T, Kirkpatrick I, Tam JW, Kashour T. Percutaneous balloon valvuloplasty for pulmonic stenosis: the role of multimodality imaging. Echocardiography. 2008 Jan;25(2):231-5.
54. Jassal DS, Hung J. Chapter: Valvular heart diseases: cardiac imaging atlas. 2008.
55. Jassal DS, King MEK. Chapter: Congenital heart disease: cardiac imaging atlas. 2008.
2007
56. Shapiro MD, Neilan TG, Jassal DS, Hoffman U, Brady TJ, Cury RC. Multidetector computed tomography for the detection of left atrial appendage thrombus: a comparative study with transesophageal echocardiography. J Comput Assist Tomogr. 2007;31(6):905-9.
57. Jassal DS, Neilan TG, Picard MH, Wood MJ. Stress echocardiography: abnormal response of tissue-Doppler derived indices to dobutamine in the absence of obstructive coronary artery disease in patients with chronic renal failure. Echocardiography. 2007;24(6):580-6.
58. Jassal DS, Neilan TG, Shapiro MD, Chaithiraphan V, Ferencik M, Brady TJ, Isselbacher EM, Cury RC. 64-Multi-detector computed tomography for detection of aortic regurgitation and quantification of severity. Invest Radiol. 2007;42:507-12.
59. Neilan TG, Blake SL, Buys ES, Raher MJ, Furutani E, Jassal DS, Perez-Sanz TM, Graveline A, Pradhan AD, Janssens SP, Ichinose F, Picard MH, Scherrer-Crosbie M, Bloch KD. Disruption of nitric oxide synthase-3 protects against the cardiac injury, dysfunction and mortality induced by doxorubicin. Circulation. 2007;116(5):506-14.
60. Jassal DS, Neilan TG, Fatima U, Holmvang G, Agnihotri A, Palacios I, Yoerger DM. Mitral valve ring dehiscence with an aorta-left atrial fistula. Eur J Echocardiography. 2007;8(4):296-8.
61. Jassal DS, Thakrar A, Neilan TG, Isselbacher EM, Brugge WR, King ME. Cardioembolic stroke in a patient with spindle cell carcinoma of the left atrium. J Am Soc Echocardiogr. 2007;Apr;20(4):438e1-4.
62. Jassal DS, Aminbakhsh A, Fang T, Shaikh N, Embil JM, Mackenzie GS, Tam JW. Diagnostic value of harmonic transthoracic echocardiography in native valve infective endocarditis: comparison with transesophageal echocardiography. Cardiovasc Ultrasound. 2007;5:20.
63. Butler J, Shapiro M, Jassal DS, Neilan TG, Nichols J, Ferencik M, Brady TJ, Hoffmann U, Cury RC. Comparison of multi-detector computed tomography and two-dimensional transthoracic echocardiography for left ventricular assessment in patients with heart failure. Am J Cardiol. 2007;99(2):247-9.
64. Raoult D, Abbara S, Jassal DS, Kradin R. Case records of the Massachusetts General Hospital. Case 5-2007. A 53-year-old man with a prosthetic aortic valve and recent onset of fatigue, dyspnea, weight loss and sweats. N Engl J Med. 2007;356(7):715-25.
65. Thakrar A, Shapiro MD, Jassal DS, Neilan TG, King ME, Abbara S. Cor triatriatum: the utility of cardiovascular imaging. Can J Cardiol. 2007 Feb;23(2):143-5.
66. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Lim CC, Masao K, Picard MH, Scherrer-Crobie M, Janssens S, Liao Ronglih, and Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res. 2007;100(1):130-9.
2006
67. Jassal DS, Desai SC, Neilan TG, Avery E, Vlahakes GJ, and Agnihotri A. The impact of spontaneous echocardiographic contrast in patients with left atrial enlargement undergoing cardiac valvular surgery. J Cardiothorac Vasc Anesth. 2006;20(6):772-6.
68. Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu TT, Yoerger DM, Jassal DS, Lewandrowski KB, Siegel AJ, Marshall JE, Douglas PS, Lawlor D, Picard MH, Wood MJ. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation. 2006;114(22):2325-33.
69. Jassal DS, Chaithiraphan V, Neilan TG, Cury RC. Delayed contrast enhancement CMR imaging in apical hypertrophic cardiomyopathy. Int J Cardiol. 2006 Nov; 10;113(2):e56-7.
70. Jassal DS, Fatima U, Thakrar A, Neilan TG, Rodriguez N, Rosenberg A, Holmvang G. Mediastinal paraganglioma: utility of preoperative cardiac MRI. J Thor Cardiovasc Surg. 2006 Oct;132(4):976-7.
71. Neilan TG, Ton-Nu TT, Jassal DS, Popovic ZB, Douglas PS, Halpern EF, Marshall JE, Thomas JD, Picard MH, Yoerger DM, Wood MJ. Myocardial adaptation to short-term high-intensity exercise in highly-trained athletes. J Am Soc Echocardiogr. 2006;19(10):1280-5.
72. Neilan TG, Jassal DS, Perez-Sanz MT, Raher MJ, Buys ES, Bayne DB, Bloch KD, Picard MH and Scherrer-Crosbie M. Tissue Doppler imaging predicts left ventricular dysfunction in a murine model of cardiac injury. Eur Heart J. 2006;27(15):1868-75.
73. Jassal DS, Neilan TG, Pradhan AD, Lynch KE, Vlahakes G, Agnihotri A, and Picard MH. Surgical management of infective endocarditis: early predictors of short term morbidity and mortality. Ann Thor Surg. 2006;82(2):524-9.
74. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Sruti S, Tambouret R, Jassal DS, Raher MJ, Furtutani E, Gladwin MT, Rosenzweig A, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006;291(1):H379-84.
75. Jassal DS, Neilan TG, Palacios IF, Lowry PA, Vlahakes G, Picard MH, Fifer MA and Yoerger DM. Sustained improvement in diastolic function after alcohol septal ablation for hypertrophic obstructive cardiomyopathy. Eur Heart J. 2006;27(15):1805-10.
76. Neilan TG, Jassal DS, Chen G, Deflandre C, McAllister H, Kay E, Austin SC, Harmey JH and Fitzerald DJ. Iloprost attenuates doxorubicin-induced cardiac injury without compromising tumor suppression. Eur Heart J. 2006;7(10):1251-6.
77. Jassal DS, Hassan A, Buth KJ, Neilan TG, Koilpillai C, Hirsch GM. Surgical management of infective endocarditis. J Heart Val Dis. 2006;15(1):115-21.
78. Jassal DS, Neilan TG, and Hung J. A continuous murmur. Echocardiography. 2006 Jan;23(1):60-1.
79. Jassal DS, Neilan TG, Nomura C, Wittram C, and King ME. Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: an echocardiographic perspective. J Am Soc Echocardiogr. 2006 Jan;19(2):229.e5-229.e7.
80. Jassal DS, Nomura C, Neilan TG, Fatima U, Holmvang G, Januzzi JL, Brady T, and Cury R. Delayed contrast enhancement CMR imaging in left ventricular noncompaction. J Cardiovasc Magn Reson. 2006;8(3):489-91.
2005
81. Anderson DR, Gardner MJ, Putnam W, Jassal DS, Brownell B, Flowerdew G, Nagpal S, Thompson K and Cox JL. Population-based evaluation of the management of antithrombotic therapy for atrial fibrillation. Can J Cardio. 2005;1(3):257-66.
82. Jassal DS, Chiasson M, Rajda M, Ostry A, and Legare JF. Isolated pulmonic valve endocarditis. Can J Card. 2005;21(4):365-6.
83. Jassal DS, Yung J, Crofts P, and Stewart K. A fungal phenomenon. Perspectives in Cardiology. 2005 Jan;21(1):13-4.
2011
Aubie Angel Young Investigator Award for Clinical Research, Department of Internal Medicine, Faculty of Medicine University of Manitoba
2010
Royal College of Physicians and Surgeons of Canada 2010 Mentor of the Year Award
University of Manitoba Rh Award-Health Sciences Category
2009
Ted Cuddy Cardiology Educator of the Year Award: Section of Cardiology, Department of Internal Medicine, University of Manitoba
SIRC Canadian Research Award: The Impact of Applied Research on Athletic Excellence – High Performance Category
Top 5 Cardiology Teachers as voted by University of Manitoba postgraduate residents, University of Manitoba
Ted Cuddy Cardiology Educator of the Year Award: Section of Cardiology, Department of Internal Medicine, University of Manitoba
2008
Liam Murphy Young Investigator Award, University of Manitoba
Canadian Cardiovascular Society Young Investigator Runner-up Award
Heart and Stroke Foundation New Investigator Award
2007
F.W. DuVal Clinical Research Professorship
2006
National Research Forum for Young Investigators in Circulatory and Respiratory Health Travel Award
2005
Canadian Heart and Stroke Foundation Research Fellowship (2nd year tenure)
2004
Dalhousie Medical Research Foundation Award
Pfizer Excellence in Resident Training Award
2003
Best Oral Presentation for Subspecialty Resident, Internal Medicine Resident Research Day, Dalhousie University, Halifax, Nova Scotia.
Canadian Cardiovascular Society Student Finalist Poster Presentation: Clinical Sciences
2002
Canadian Cardiovascular Society Trainee Excellence in Teaching Award
Capital Health Research Scholarship
Dalhousie Medical Research Foundation Award
Manitoba Medical Student Association Teaching Awards: Most Outstanding Resident as voted by Graduating Class of 2002
Best Oral Presentation for Subspecialty Resident, Internal Medicine Resident Research Day, Dalhousie University, Halifax, Nova Scotia
2001
The Royal College of Physicians and Surgeons of Canada Prize for the best paper written by a Resident
Manitoba Medical Student Association Teaching Awards: Most Outstanding Resident as voted by Graduating Classes of 2001 and 2002
Winner of Research Competition at 82nd Annual American College of Physicians (ACP), Associates Competition and International Competition
2000
Health Sciences Centre Medical Staff Council Fellowship Award
Manitoba Medical Student Association Teaching Awards: Most Outstanding Resident as voted by Graduating Class of 2000
1999
Manitoba Medical Student Association Teaching Awards: Most Outstanding Resident, Medicine III and IV
Winner of Research Competition at 80th Annual American College of Physicians (ACP), Associates Competition
Manitoba Medical Student Association Teaching Awards: Most Outstanding Resident, Medicine III
Wyeth-Ayerst Prize in the Clinical Investigation Category, University of Manitoba Resident Research Day
1998
Winner of Research Competition at 79th Annual ACP, Medical Student
1997
Hollenberg Award
1995
Charles Joseph Portnuff Scholarship
1994
Canada Scholarship
1993
St. Boniface Research Centre Foundation Scholarship
1991
International Baccalaureate Degree
Governor General Medal Award
Northern Telecom Scholarship
University of Manitoba Alumni Entrance Scholarship
1. WRHA Internal Medicine/ Cardiac Sciences 2006-2011
Title: Startup funds for Advanced Small Animal Cardiovascular Imaging Laboratory
2. Manitoba Medical Services Foundation 2007-2010
Title: The utility of Tissue Doppler imaging, cardiac biomarkers and cardiac MRI in predicting early left ventricular dysfunction in patients with HER-2 positive breast cancer treated with Herceptin
3. St. Boniface General Hospital and Research Foundation 2007-2011
Title: Startup funds for Advanced Small Animal Cardiovascular Imaging Laboratory
4. F.W. DuVal Clinical Research Professorship 2007-2010
Title: Advanced Small Animal Cardiovascular Imaging Laboratory
5. Manitoba Health Research Council- Establishment 2007-2010
Title: The interaction of hyperlipidemia and NOS3 on ventricular remodeling after pressure-induced overload
6. Health Sciences Centre Foundation 2007-2009
Title: The utility of Tissue Doppler imaging, cardiac biomarkers and cardiac MRI in predicting early left ventricular dysfunction in patients with HER-2 positive breast cancer treated with Herceptin
7. The Dr. Paul H.T. Thorlakson Foundation Fund 2007-2010
Title: Early diagnosis and mitigation of left ventricular dysfunction in a murine model of anthracycline induced cardiomyopathy
8. F.W. DuVal Clinical Research Professorship: Grant-in-aid 2007-2010
Title: Utility of Tissue Doppler imaging, cardiac MRI and biomarkers in the assessment of LV remodeling in obstructive sleep apnea
9. Heart and Stroke Foundation New Investigator Award 2008-2013
Title: The interaction of hyperlipidemia and NOS3 on ventricular remodeling after pressure-induced overload
10. Manitoba Health Research Council-Operating 2008-2011
Title: Prophylactic use of renin inhibition, ACE inhibition and angiotensin receptor blockade in the prevention of trastuzumab mediated cardiomyopathy
11. CIHR Regenerative Medicine Team Grant (co-applicant) 2008-2013
Title: Development of a multidisciplinary stem-cell program to fight congestive heart failure
12. Manitoba Medical Services Foundation (co-applicant) 2009-2010
Title: Dynamic novel cardiac imaging parameters in nocturnal home hemodialysis
13. University Research Grants Project 2009-2011
Title: Prevention of accelerated atherosclerosis and ischemic heart disease in the ApoE/NOS3 double-knockout mouse model of the metabolic syndrome
14. Canada Indirect Costs Program 2009-2010
Title: Cardiovascular magnetic resonance imaging CMR42 software
15. Canada Summer Jobs Funding 2009-2010
Title: Advanced small animal cardiovascular imaging laboratory
16. Canada Foundation for Innovation: Infrastructure Operating 2010-2011
Title: Advanced small animal cardiovascular imaging laboratory
17. CIHR Team Grant (co-applicant) 2010-2014
Title: FGF2 isoforms in cardiac hypertrophy
18. Canadian Breast Cancer Foundation (Co-Principal Applicant) 2010-2012
Title: Novel approaches in reducing morbidity and mortality in breast cancer patients
19. Canada Indirect Costs Program 2010-2011
Title: Visualsonics Small Animal Imaging Platform
20. Manitoba Medical Services Foundation (co-applicant) 2011-2012
Title: Development of novel MRI techniques to improve the diagnosis of congenital and valvular heart diseases
21. Canada Indirect Costs Program 2011-2013
Title: GE Small Animal Imaging Platform
22. CIHR Operating Grant (co-applicant) 2011-2014
Title: Protective signaling by PPARS in cardiac hypertrophy
There are no opportunities available at this time.
