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Dr. Davinder S. Jassal

Dr. Davinder S. Jassal

Principal Investigator
Cardiovascular Imaging, Institute of Cardiovascular Sciences

Professor
Department of Internal Medicine, University of Manitoba

Research Focus

Dr. Jassal’s research focuses on the complementary use of multimodality cardiovascular imaging in the noninvasive assessment of heart failure syndromes. Using a combination of echocardiography (ultrasound of the heart), cardiac CT (computed tomography), and CMR (cardiac MRI), the Cardiovascular Imaging Laboratory at St. Boniface Hospital Research is dedicated to translational research focusing on three heart failure models:

1. Cardio-Oncology: Breast Cancer and Heart failure

Breast cancer and cardiovascular disease are major public health concerns in Canada. The two diseases are intricately involved as treatment of one disease may lead to detrimental effects in the other. Although the current combination of surgical resection, radiotherapy, and chemotherapy may lead to remission in breast cancer patients, the administration of chemotherapeutic based agents, in particular Doxorubicin, are associated with an increased risk of cardiotoxicity. The introduction of novel monoclonal antibodies in breast cancer therapy which target growth factor receptors further compounds this issue of drug induced cardiac dysfunction. Trastuzumab (Herceptin), a humanized monoclonal antibody against the extracellular domain of the HER-2 protein, is used in both the adjuvant and metastatic settings of breast cancer. Despite its clear therapeutic benefits, cardiotoxicity is a major concern, especially when Trastuzumab is used in combination with anthracyclines. Although clinical trials have demonstrated that the risk of developing LV systolic dysfunction after receiving Trastuzumab is up to 10%, recent studies have shown an even higher risk of nearly 1 in 4 women developing this drug induced cardiomyopathy. An understanding of the potential mechanisms for the deleterious cardiac effects of HER-2 blockade may be beneficial in improving breast cancer therapy. Our current focus is to evaluate the cardioprotective effect of the anti-oxidant, n-acetylcysteine amide (NACA), against the drug-induced cardiotoxicity caused by Doxorubicin and Traztuzumab. The anticipated goal of our Cardio-Oncology research program is to improve overall morbidity and mortality in cancer patients treated with chemotherapy, while at the same time, preventing any detrimental side effects of these drugs on cardiac health.

2. ASICS (Avastin and Sutent Induced Cardiotoxicity Study)

Colorectal and kidney cancer are major public health concerns in North America, affecting both men and women equally. Although the current combination of surgery, radiation, and chemotherapy may lead to remission in this cancer population, the administration of chemotherapeutic drugs is associated with an increased risk of developing heart failure. While the recent addition of Bevacizumab (BVZ) and Sunitinib (SNT) may improve the long-term outcomes in individuals with colorectal and kidney cancers, these two drugs may also increase the risk of developing heart failure. We are studying the role of cardiac biomarkers and novel imaging techniques in the early detection of BVZ and SNT mediated cardiotoxicity at both the basic science level and in the clinical setting. Additionally, we are currently evaluating the use of RAS inhibitors (Aliskiren, Perindopril, or Valsartan) as prophylactic agents in the prevention of BVZ and SNT mediated cardiotoxicity.

3. Marathon Running and Heart Failure

Can too much exercise be detrimental to your health? Physical fitness has been shown to be an independent, long-term predictor of reduced morbidity and mortality from cardiovascular causes. Although the cardiovascular benefits of moderate exercise are well established, the cardiovascular effects of prolonged exertion, including marathon running, are less clear. Even though the risk of sudden death associated with participation in marathons is small, participation in such events is consistently associated with biochemical evidence of heart damage and dysfunction. Using cardiac biomarkers, echocardiography, cardiac CT, and cardiac MRI, Dr. Jassal is evaluating the effects of marathon running on cardiac function through our participation with the 2006-2015 Manitoba Marathons.

4.CHIRP (Cardiac Hemodynamic Imaging and Remodeling in Pregnancy)

The progression of pregnancy causes multiple physiologic changes in the female cardiovascular system. Such changes include enlargement of all four cardiac chambers, increased left ventricular wall thickness, mild valvular regurgitation, and an increase in both plasma volume and cardiac output by 40%.

Structural and functional changes that develop during pregnancy have previously been investigated by numerous methods, and echocardiography is currently the standard modality. Due to the inherent limitations of echocardiography, we are investigating the use of cardiac MRI to study the changes in cardiac physiology during pregnancy.

The objective of the CHIRP Study is to determine the range of normal structural and functional changes of the heart during a healthy pregnancy by employing both cardiac echocardiography and MRI.

What techniques and equipment are used in this laboratory?

As a Clinician-Scientist, Dr. Jassal has established a world class advanced small animal cardiovascular imaging laboratory at SBRC with the acquisition of both the GE Vivid 7 and Visualsonics Vevo 2100 machines through the support of the CFI-LOF New Investigator program (only laboratory with both imaging platforms in Western Canada). Five dedicated postprocessing work stations are located in Dr. Jassal’s laboratory, Rm 4010 for analysis of the images using standard M-Mode, 2D echocardiography, color Doppler and Tissue Doppler imaging. The work stations are also used for postprocessing of cardiac CT and MRI images.

To delineate mechanistic pathways involved in the cardiovascular remodeling assessed by murine echocardiography, the lab is also equipped with histological and immunohistochemistry techniques.

About Dr. Davinder S. Jassal

Dr. Jassal was born in Thompson, Manitoba, obtained an International Baccalaureate Degree at Sisler High School in Winnipeg, and graduated from the University of Manitoba with an MD in 1998. He completed a residency in Internal Medicine at the University of Manitoba from 1998-2001 and a residency in Cardiology at Dalhousie University in Halifax, Nova Scotia, Canada. Subsequently, he completed a clinical and research fellowship in Cardiac Imaging specializing in echocardiography, computed tomography, and MRI at Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Dr. Jassal rejoined the Section of Cardiology, Department of Internal Medicine, Faculty of Medicine at the University of Manitoba in 2006 as an Academic Clinician Scientist, where half of his time is devoted to patient care in CCU and cardiac imaging and the other half devoted to translational research. He is currently Associate Professor of Cardiology, Oncology, Radiology, and Physiology, Principal Investigator of the Cardiovascular Imaging Laboratory as a member of the Institute of Cardiovascular Sciences, and is the Track Captain for Cardiovascular Imaging for the Canadian Cardiovascular Society.

For more information, please contact:

Dr. Davinder S. Jassal
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. (204) 237-2599
Lab Office. (204) 235-3056
Hospital Office. (204) 237-2023
Fax. (204) 233-2157
Email. djassal@sbgh.mb.ca

Mr. David YC Cheung
Research Technician
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. (204) 237-2599, (204) 235-3741
Fax. (204) 233-6723
Email. dcheung@sbrc.ca

2015

1. Liu S, Moussa M, Wassef AW, Hiebert BM, Hussain F, Jassal DS. The Utility of Systolic and Diastolic Echocardiographic Parameters for Predicting Coronary Artery Disease Burden as Defined by the SYNTAX Score. Echocardiography. 2015 Jun 26.

2. Kinley DJ, Lowry H, Katz C, Jacobi F, Jassal DS, Sareen J. Depression and anxiety disorders and the link to physician diagnosed cardiac disease and metabolic risk factors. Gen Hosp Psychiatry. 2015 Jul-Aug;37(4):288-93.

2. Bordun KA, Premecz S, daSilva M, Mandal S, Goyal V, Glavinovic T, Cheung M, Cheung D, White CW, Chaudhary R, Freed DH, Villarraga HR, Herrmann J, Kohli M, Ravandi A, Thliveris J, Pitz M, Singal PK, Mulvagh SL, Jassal DS. The utility of cardiac biomarkers and echocardiography for the early detection of Bevacizumab and Sunitinib mediated cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015 Jun 19:ajpheart.00172.2015

3. McIntyre WF, Jassal DS, Morris AL. Pericardial effusions: do they all require pericardiocentesis? Can J Cardiol. 2015 Jun; 31(6); 812-5.

4. Holmes S, Kirkpatrick ID, Zelop CM, Jassal DS. MRI evaluation of maternal cardiac displacement in pregnancy: implications for cardiopulmonary resuscitation. Am J Obstet Gynecol. 2015 May 14.

5. Akolkar G, Bhullar N, Bews H, Shaikh B, Premecz S, Bordun KA, Cheung DY, Goyal V, Sharma AK, Garber P, Singal PK, Jassal DS. The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicity. Cardiovasc Ultrasound. 2015 Apr 3;13(1):18

6. Lau L, Ducas R, Rizkallah J, Jassal DS, Seifer CM. The utility of pocket-sized echocardiography to assess left ventricular systolic function prior to permanent pacemaker implantation. Cardiovasc Ultrasound. 2015 Mar 14;13(1):10

7. Rech L, Premecz S, Jassal DS, Zahradka P, Taylor C. Dietary analysis of full marathon runners over 50 years of age: a retrospective study. J Sports Med Phys Fitness. 2015 Mar 24.

8. Goyal V, Bews H, Shaikh N, Hussain F, Jassal DS. Multimodality cardiac imaging of a left ventricular thrombus: a case report. BMC Res Notes. 2015 Feb 28;8:59

9. Zeglinski MR, Hnatowich M, Jassal DS, Dixon IMC. SnoN as a Novel Negative Regulator of TGF-β/Smad Signaling: A Target for Tailoring Organ Fibrosis. AJP Heart Circ Rev. 2015 Jan;308(2):H75-82.

2014

1. Glavinovic T, Cheung DY, Cordova Perez FJ, Soni A, Memauri B, Jassal DS. Right ventricular free wall dyskinesis in the setting of left ventricular non compaction: a case report. BMC Res Notes. 2014 Nov 5;7:787

2. Golian M, Freed D, Jassal DS, Ravandi A. Successful cardiac resuscitation with extracorporeal membrane oxygenation in the setting of persistent ventricular fibrillation: a case report. BMC Res Notes. 2014 Nov 4;7:782

3. Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal DS, Fernyhough P, Down GW 2nd, Kirshenbaum LA. Bnip 3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci USA. 2014 Dec;111(51):E5537-44.

4. Sharma AK, Ludke AR, Bagchi AK, Al-Shudiefat AA-R, Akolkar G, Jassal DS, Singal PK. Phosphorylation of AktSer473/Ask1Ser83 in Trolox-induced suppression of doxorubicin-induced changes in rat cardiomyocytes. Curr Res Cardiol. Vol. 1 No. 1 Autumn 2014.

5. Karlstedt E, Jassal DS, Kirkpatrick ID, Freed D, Seifer CM. Multimodality cardiac imaging of infective endocarditis. J Cardiovasc Med (Hagerstown). 2014 Jul 10.

6. Saeed MF, Premecz S, Goyal V, Singal PK, Jassal DS. Catching broken hearts: pre-clinical detection of doxorubicin and trastuzumab mediated cardiac dysfunction in the breast cancer setting. Can J Physiol Pharmacol. 2014 Jul;92(7):546-50.

7. Liu S, Horne D, Freed DH, Sookhoo S, Strzelcyzk J, Ravandi A, Jassal DS. Multimodality cardiac imaging of cardiac pheochromocytoma. J Am Coll Cardiol. 2014 Jun 17;63(23):e189

8. Friesen T, Jassal DS, Zhu M, Eng F, Rigatto C, Tangri N, Sood MM, Karlstedt E, Premecz S, Komenda P. Cardiovascular remodeling during long-term nocturnal home hemodialysis. Clin Exp Nephrol. 2014 Jun 4.

9. Zeglinski M, Premecz S, Lerner J, Wtorek J, daSilva M, Hasanally D, Chaudhary R, Sharma A, Thliveris J, Ravandi A, Singal PK, Jassal DS. Congenital absence of nitric oxide synthase 3 potentiates cardiac dysfunction and reduces survival in Doxorubicin- and Trastuzumab-mediated cardiomyopathy. Can J Cardiol. 2014. Mar;30(3):359-67

10. Ducas RA, Elliott JE, Melnyk SF, Premecz S, daSilva M, Cleverley K, Wtorek P, Mackenzie GS, Helewa ME, Jassal DS. Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodymanic imaging and remodeling in pregnancy (CHIRP) study. J Cardiovasc Magn Reson. 2014 Jan; 16(1):1.

2013

1. Cleverley K, Du X, Premecz S, Le K, Zeglinski M, Nicholson T, Goh CY, Lu Y, Anderson HD, Moghadasian MH, Jassal DS. Does Fish oil Consumption Reduce Cardiovascular Complications in ApoE Deficient Mice? Can J Physiol Pharmacol. 2013 Nov;91(11):960-5.

2. Elmayergi N, Nguyen Tm Hiebert B, Philipp RK, Jassal DS, Tam JW, Hussasin F. a “no-option” left main PCI registry: Outcomes and predictors of in hospital mortality-utility of the logistic EuroSCORE. Catheter Cardiovasc Interv. 2013 Sep 1;82(3):361-9

3. Cleverley K, Mousavi N, Stronger L, Ann-Bordun K,Hall L, Tam JW, Tischenko A, Jassal DS, Philipp RK. The impact of telemetry on survival of in-hospital cardiac arrests in non-critical care patients. Resuscitation. 2013 Jul;84(7):878-82.

4. Shen S, Rizkallah J, Kirkpatrick ID, Khadem A, Jassal DS. Cardiac lipofibromatosis. Can J Cardiol. 2013 Apr;29(4):519.e11-2

5. Kumar K, Nepomuceno RG, Chelvanathan A, Golian M, Bohonis S, Cleverley K, Ravandi A, Mackenzie S, Jassal DS. The role of tissue Doppler imaging in predicting left ventricular filling pressures in patients undergoing cardiac surgery: an intraoperative study. Echocardiography. 2013 Mar;30(3):271-8.

6. Ducas R, Tsang W, Chong AA, Jassal DS, Lang RM, Leong-Poi H, Chan KL. Echocardiography and vascular ultrasound: new developments and future directions. Can J Cardiol. 2013 Mar;29(3):304-16.

7. Epp RA, Susser SE, Morissettee MP, Kehler DS, Jassal DS, Duhamel TA. Exercise training prevents the development of cardiac dysfunction in the low-dose streptozotocin diabetic rats fed a high-fat diet. Can J Physiol Pharmacol. 2013 Jan;91(1):80-9.

2012

1. Shen S, Rizkallah J, Kirkpatrick ID, Khadem A, Jassal DS. Cardiac Lipofibromatosis. Can J Cardiol. 2012 Nov 9. doi:pii: S0828-282X(12)01269-X. 10.1016/j.cjca.2012.08.018.

2. 11. Cenkowski M, daSilva M, Bordun KA, Hussain F, Kirkpatrick ID, Jassal DS. Spontaneous dissection of the coronary and vertebral arteries post-partum: a case report. BMC Pregnancy Childbirth. 2012 Nov 2;12:122.

3. Dhaliwal S, Ducas R, Shuangbo L, Horne D, Lee J, Hussain F, Kirkpatrick ID, Jassal DS. Multimodality cardiac imaging of a ventricular septal rupture post myocardial infarction: a case report. BMC Res Notes. 2012 Oct 25;5:583.

4. Kha LC, Cassano-Bailey A, Cleverley K, Sud M, Strzelczyk J, Jassal DS. Multimodality cardiac imaging of a double chambered right ventricle with intrapulmonary shunting: a case report. BMC Res Notes. 2012 Oct 2;5:544.

5. Altuwaijri WA, Kirkpatrick ID, Jassal DS, Soni A. Vanishing left ventricular thrombus in a woman with peripartum cardiomyopathy: a case report. BMC Res Notes. 2012 Oct 2;5:544.

6. Hussain F, Nguyen T, Elmayergi N, Ducas J, Minhas K, Vo M, Kass M, Ravandi A, Parmar G, Jassal DS, Tam JW, Freed D, Menkis AH, Philipp RK. The acutely occluded left main coronary artery culprit in cardiogenic shock and initial percutaneous coronary intervention: a substudy of the Manitoba “no option” left main PCI registry. Can J Physiol Pharmacol. 2012 Sep;90(9):1325-31. Epub 2012 Aug 22.

7. Karlstedt E, Chelvanathan A, Da Silva M, Cleverley K, Kumar K, Bhullar N, Lytwyn M, Bohonis S, Oomah S, Nepomuceno R, Du X, Melnyk S, Zeglinski M, Ducas R, Sefidgar M, Mackenzie S, Sharma S, Kirkpatrick ID, Jassal DS. The impact of repeated marathon running on cardiovascular function in the aging population. J Cardiovasc Magn Reson. 2012 Aug 20;14:58.

8. Horne D, Jassal DS, Mysore S, Kirkpatrick ID, Freed DH, HUssain F. Multimodality imaging of a right atrial myxoma with pulmonary embolization. Can J Cardiol. 2012 Jul-Aug;28(4):516.

9. Ducas RA, Wassef AW, Jassal DS, Weldon E, Schmidt C, Grierson R, Tam JW. To transmit or not to transmit: how good are emergency medical personnel in detecting STEMI in patients with chest pain? Can J Cardiol. 2012 Jul-Aug; 28(4): 432-7.

10. Ducas RA, Philipp RK, Jassal DS, Wassef AW, Weldone E, Hussain F, Schmidt C, Khadem A, Ducas J, Grierson R, Tam JW. Cardiac outcomes through digital evaluation (CODE) STEMI project: prehospital digitally-assisted reperfusion strategies. Can J Cardiol. 2012 Jul-Aug; 28(4): 423-31.

11. Tsang JF, Lytwyn M, Farag A, Zeglinski M, Wallace K, Dasilva M, Bohonis S, Walker JR, Tam JW, Strzelczyk J, Jassal DS. Multimodality imaging of aortic dimensions: comparison of transthoracic echocardiography with multidetector row computed tomography. Echocardiograpy. 2012 Jul;29(6):735-41.

12. Colish J, Walker JR, Elmayergi N, Almutairi S, Alharbi F, Lytwyn M, Francis A, Bohonis S, Zeglinski M, Kirkpatrick ID, Sharma S, Jassal DS. Obstructive sleep apnea: effects of continuous positive airway pressures on cardiac remodeling as assessed by cardaic biomarkers, echocardiography and cardiac MRI. Chest 2012 Mar; 141(3): 674-81.

2011

1. Burwash IG, Basmadijian A, Bewick D, Choy JB, Cujec B, Jassal DS, Mackenzie S, Nair P, Rusdki LG, Yu E, Tam JW. 2010 Canadian Cardiovascular Society/Canadian Society of Echocardiography Guidelines for Training and Maintenance of Competency in Adult Echocardiography. Can J Cardiol. 2011 Nov-Dec; 27(6): 862-4.

2. Ducas R, Ariyarajah V, Phillipp R, Ducas J, Elliott J, Jassal DS, Tam JW, Garber P, Shaikh N, Hussain F. The presence of ST-elevation in lead aVR predicts signficiant left main coronary artery stenosis in cardiogenic shock resulting from myocardial infarction: the Manitoba cardiogenic shock registry. Int J Cardiol 2011; Nov 27.

3. Jiminez SK, Jassal DS, Kardami E, Cattini PA. Protection by endogenous FGF-2 against isoproterenol-induced cardiac dysfunction is attenuated by cyclosporine A. Mol Cell Biochem. 2011 Nov;357(1-2):1-8.

4. Hussain F, Philipp R, Ducas R, Elliot J, Dzavik V, Jassal DS, Tam JW, Roberts D, Garber P, Ducas J. The ability to achieve complete revascularization is associated with in-hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic shock registry investigators. Catheter Cardiovasc Interv. 2011 Oct1;78(4):540-8.

5. Zeglinski M, Ludke A, Jassal DS, Singal PK. Trastuzumab-induced cardiac dysfunction: a ‘dual-hit’. Exp Clin Cardiol. 2011 Fall; 16(3): 70-4.

6. Fallah-Rad N, Walker JR, Wassef A, Lytwyn M, Bohonis S, Fang T, Tian G, Kirkpatrick ID, Singal PK, Krahn M, Grenier D, Jassal DS. The utility of cardiac biomarkers, tissue velocit and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor-II positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol 2011 May 31; 57(22): 2263-70.

7. Jiminez SK, Jassal DS, Kardami E, Cattini PA. A single bout of exercise promotes sustained left ventricular function after isoproterenol-induced injury in mice. J Physiol Sci. 2011 Jul;61(4):331-6.

8. Kotrec M, Jassal DS, Zieroth S, Freed DH, Tam JW. Ventricular septal defect as a result of direct trauma from mechanical mitral valve prosthesis. Can J Cardiol. 2011 Mar-Apr;27(2):263.e21-3.

9. Garber PJ, Hussain F, Koenig JK, Maycher B, Jassal DS. Multimodality imaging of a coronary artery fistula after septal myomectomy in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2011 Mar 1;57(9):e95.

10. Walker JR, Sharma A, Lytwyn M, Bohonis S, Thliveris J, Singal PK, Jassal DS. The cardioprotective role of probucol against anthracycline and trastuzumab mediated cardiotoxicity. J Am Soc Echocardiogr. 2011 Feb 23.

11. Gillingham L, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapseed and flaxseed oils modulate serum lipid and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutrit. 2011 Feb;105(3):417-27.

12. Oomah S, Mousavi N, Bhullar N, Kumar K, Walker JR, Lywtyn M, Colish J, Wassef A, Kirkpatrick ID, Sharma S, Jassal DS. The role of three dimensional echocardiography in the assessment of right ventricular dysfunction after a half marathon: comparison with cardiac magnetic resonance imaging. J Am Soc Echocardiogr. 2011 Feb; 24(2): 207-13

13. Jassal DS, Bhagirath KM, Karlstedt E, Zeglinski M, Dumesnil JG, Teo KK, Tam JW, Chan KL. Evaluating the effectiveness of rosuvastatin in preventing the profession of diastolic dysfunction in aortic stenosis: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. Cardiovasc Ultrasound. 2011 Feb 7;9(1): 5.

2010

1. Ariyarajah V, Hussain F, McGregor R, Raabe M, Menkis A, Jassal DS. Progression of low-pressure to acute classic cardiac tamponade: a diagnostic dilemma in the setting of spontaneous left ventricular rupture. Am Heart Hosp J. 2010 Winter;8(2):E133-5.

2. Lytwyn M, Fallah-Rad N, Walker JR, Bohonis S, Hussain F, Barac I, Jassal DS. The utility of dobutamine stress echocardiography for the diagnosis of coronary artery disease in the HIV population. Echocardiography. 2010 Nov;27(10):1228-32.

3. Han CS, Bohonis S, Walker JR, Vo M, Hussain F, Pascoe E, Jassal DS. An unusual presentation of left ventricular free wall rupture. Can J Cardiol. 2010 Oct;26(8):328-9.

4. Walker JR, Bhullar N, Fallah-Rad N, Lytwyn M, Golian M, Fang T, Summers AR, Singal PK, Barac I, Kirkpatrick ID, Jassal DS. The role of 3D echocardiography in breast cancer: comparison with 2D echocardiography, MUGA and cardiac MRI. J Clin Oncol. 2010 Jul 20;28(21):3429-36.

5. Ariyarajah V, Shaikh N, Garber PJ, Kirkpatrick IDC, McGregor R, Jassal DS. Cardiovascular magnetic resonance in mild to moderate clozapine-induced myocarditis: is there a role in absence of electrocardiographic and echocardiographic abnormalities? J Magn Reson Imaging. 2010 Jun;31(6):1473-6.

6. Mousavi N, Czarnecki A, Ahmadie R, Fang T, Kumar K, Lytwyn M, Kumar A, Jassal DS. The utility of Tissue Doppler imaging for the noninvasive determination of left ventricular filling pressures in patients with septic shock. J Intensive Care Med. 2010 May-Jun;25(3):163-7

7. Mousavi N, Jassal DS, Moon M, Shaikh N, Soni A. Thrombus in transit. Can J Cardiol. 2010 Mar;26(3):e133.

8. Jassal DS, Bhagirath KM, Tam JW, Sochowski RA, Dumesnil JG, Giannoccaro PJ, Jue J, Pandey AS, Joyner CD, Teo KK, Chan KL. Association of bicuspid aortic valve morphology and aortic root dimensions: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study. Echocardiography. 2010 Feb:27(2); 174-9.

9. Ahraf F, Jassal DS, Kirkpatrick ID, Tam J. Multimodality imaging of an old organized hemopericardium. Can J Cardiol. 2010 Jan;26(1):e33-4.

10. Walker JR, Lee J, Strzelczyk J, Jassal DS, Soni A. Congenital aorta to right atrial fistula. Cardiol J. 2010;17(5):523-4.


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2015

Research Manitoba Mid-Career Award

Manitoba Medical Student’s Association Med I Teaching Innovation Award

2013

Kern Wildenthal Clinical Investigation Award in Cardiovascular Sciences, International Academy of Cardiovascular Sciences

2012

Faculty of Medicine Teaching Award as voted by Medicine I, University of Manitoba

2011

Aubie Angel Young Investigator Award for Clinical Research, Department of Internal Medicine, Faculty of Medicine University of Manitoba

Top 7 Internal Medicine Teachers as voted by University of Manitoba Internal Medicine residents, University of Manitoba

Faculty of Medicine Teaching Award as voted by Medicine I, University of Manitoba

2010

Royal College of Physicians and Surgeons of Canada 2010 Mentor of the Year Award

University of Manitoba Rh Award-Health Sciences Category

Top 5 Cardiology Teachers as voted by University of Manitoba postgraduate residents, University of Manitoba

Faculty of Medicine Teaching Award as voted by Medicine I, University of Manitoba

2009

Ted Cuddy Cardiology Educator of the Year Award: Section of Cardiology, Department of Internal Medicine, University of Manitoba

SIRC Canadian Research Award: The Impact of Applied Research on Athletic Excellence – High Performance Category

Top 5 Cardiology Teachers as voted by University of Manitoba postgraduate residents, University of Manitoba

Ted Cuddy Cardiology Educator of the Year Award: Section of Cardiology, Department of Internal Medicine, University of Manitoba

Faculty of Medicine Teaching Award as voted by Medicine I, University of Manitoba

2008

Liam Murphy Young Investigator Award, University of Manitoba

Canadian Cardiovascular Society Young Investigator Runner-up Award

Heart and Stroke Foundation New Investigator Award

2007

F.W. DuVal Clinical Research Professorship

Diagnostic Services Manitoba Operating Grant 2017

Title: Scleraxis as a biomarker for cardiac fibrosis in hypertrophic cardiomyopathy

PI: Davinder S. Jassal (Section of Cardiology, Department of Internal Medicine)
Co-applicants: Dr. Iain Kirkpatrick (Department of Radiology) and Dr. Michael Czubryt (Department of Physiology and Pathophysiology)

Research Manitoba Mid-Career Operating Grant 2015-2017

Title: The prophylactic role of renin-angiotensin system antagonists in the prevention of Avastin and Sutent mediated cardiotoxicity

CancerCare Manitoba Operating Grant 2015-2017

Title: The art of preventing broken hearts in colorectal and renal cell cancer

CancerCare Manitoba Operating Grant 2013-2015

Title: The impact of Doxorubicin and Trastuzumab on cardiac cytoarchitecture and function: insights into the prevention of chemotherapy mediated cardiotoxicity in breast cancer

CAN-USA Grant 2012-2014

Title: Early Detection of Broken Hearts in Cancer Patients: Bevacizumab, Sunitinib and Heart Failure

Bilinkoff Fund 2012-2013

Title: Advanced cardiovascular imaging laboratory

Diagnostic Services of Manitoba 2012-2013

Title: CHIRP (Cardiac hemodynamic imaging and remodeling in pregnancy)

CIHR Operating Grant (co-applicant) 2011-2014

Title: Protective signaling by PPARS in cardiac hypertrophy

Canada Indirect Costs Program 2011-2013

Title: GE Small Animal Imaging Platform

Manitoba Medical Services Foundation (co-applicant) 2011-2012

Title: Development of novel MRI techniques to improve the diagnosis of congenital and valvular heart diseases

Canada Summer Jobs Funding 2011-2012

Title: Advanced small animal cardiovascular imaging laboratory

Canada Indirect Costs Program 2010-2011

Title: Visualsonics Small Animal Imaging Platform

Canadian Breast Cancer Foundation (Co-Principal Applicant) 2010-2012

Title: Novel approaches in reducing morbidity and mortality in breast cancer patients

CIHR Team Grant (co-applicant) 2010-2014

Title: FGF2 isoforms in cardiac hypertrophy

Canada Foundation for Innovation: Infrastructure Operating 2010-2011

Title: Advanced small animal cardiovascular imaging laboratory

Canada Summer Jobs Funding 2009-2010

Title: Advanced small animal cardiovascular imaging laboratory

Canada Indirect Costs Program 2009-2010

Title: Cardiovascular magnetic resonance imaging CMR42 software

University Research Grants Project 2009-2011

Title: Prevention of accelerated atherosclerosis and ischemic heart disease in the ApoE/NOS3 double-knockout mouse model of the metabolic syndrome

Manitoba Medical Services Foundation (co-applicant) 2009-2010

Title: Dynamic novel cardiac imaging parameters in nocturnal home hemodialysis

CIHR Regenerative Medicine Team Grant (co-applicant) 2008-2013

Title: Development of a multidisciplinary stem-cell program to fight congestive heart failure

Manitoba Health Research Council-Operating 2008-2011

Title: Prophylactic use of renin inhibition, ACE inhibition and angiotensin receptor blockade in the prevention of trastuzumab mediated cardiomyopathy

Heart and Stroke Foundation New Investigator Award 2008-2013

Title: The interaction of hyperlipidemia and NOS3 on ventricular remodeling after pressure-induced overload

F.W. DuVal Clinical Research Professorship: Grant-in-aid 2007-2010

Title: Utility of Tissue Doppler imaging, cardiac MRI and biomarkers in the assessment of LV remodeling in obstructive sleep apnea

The Dr. Paul H.T. Thorlakson Foundation Fund 2007-2010

Title: Early diagnosis and mitigation of left ventricular dysfunction in a murine model of anthracycline induced cardiomyopathy

Health Sciences Centre Foundation 2007-2009

Title: The utility of Tissue Doppler imaging, cardiac biomarkers and cardiac MRI in predicting early left ventricular dysfunction in patients with HER-2 positive breast cancer treated with Herceptin

Manitoba Health Research Council- Establishment 2007-2010

Title: The interaction of hyperlipidemia and NOS3 on ventricular remodeling after pressure-induced overload

F.W. DuVal Clinical Research Professorship 2007-2010

Title: Advanced Small Animal Cardiovascular Imaging Laboratory

Manitoba Medical Services Foundation 2007-2010

Title: The utility of Tissue Doppler imaging, cardiac biomarkers and cardiac MRI in predicting early left ventricular dysfunction in patients with HER-2 positive breast cancer treated with Herceptin

St. Boniface Hospital and Research Foundation 2007-2013

Title: Startup funds for Advanced Small Animal Cardiovascular Imaging Laboratory

WRHA Internal Medicine/ Cardiac Sciences 2006-2013

Title: Startup funds for Advanced Small Animal Cardiovascular Imaging Laboratory

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