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Dr. Davinder S. Jassal

Dr. Davinder S. Jassal

Principal Investigator
Cardiovascular Imaging, Institute of Cardiovascular Sciences

Professor
Department of Internal Medicine, University of Manitoba

Research Focus

Dr. Jassal’s research focuses on the complementary use of multimodality cardiovascular imaging in the non-invasive assessment of heart failure syndromes. Using a combination of echocardiography (ultrasound of the heart), cardiac CT (computed tomography), and CMR (cardiac MRI), the Cardiovascular Imaging Laboratory at St. Boniface Albrechtsen Research Centre is dedicated to translational research in the fields of Cardio-Oncology, Women’s Heart Health, and Sudden Cardiac Death.

1. FANTAM 2 study (Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity)

Cardio-Oncology is an evolving discipline that focuses on the prevention, diagnosis, and management of cancer patients who are at risk of developing heart problems as a result of their cancer treatment. As breast cancer remains a significant clinical problem in women, chemotherapy continues to be a routine treatment strategy for this patient population. Doxorubicin and Trastuzumab (DOX+TRZ) are two of the most effective anti-cancer drugs available for women with breast cancer. However, these two anti-cancer drugs may lead to heart failure in as many as 8000 Canadian women annually. Dietary interventions represent a complementary approach to the treatment of women with breast cancer. Approximately 30% of women with breast cancer use flaxseed (FLX). In the FANTAM 2 study, we will explore the means by which FLX can prevent and treat heart failure caused by the anti-cancer drugs DOX+TRZ. The results of this program will have a significant impact on improving the cardiovascular outcomes in women with breast cancer in Canada.

2. CANFLAX study (Can flax “milk” prevent broken hearts in women with breast cancer?)

Manitoba’s flaxseed (FLX) industry has seen a decline in production over the last four years. One way to revive the industry would be to focus on ways to facilitate an increase in FLX consumption. Pizzey Ingredient’s FLX “milk” is a breakthrough advancement for dietary FLX, providing an easy and delicious way to consume over 30 g of FLX on a daily basis. In the growing market of non-dairy “milk” products, including almond, soy, and coconut “milk”, the demand for these plant-based beverages continues to be driven by their increased health benefits. FLX “milk”, with its health-promoting components including omega-3 fatty acid, alpha-linolenic acid, and plant lignans, is a new alternative in this expanding global market of non-dairy “milk” products.

As Manitoba continues to be one of the top FLX producers in the world, there is an increasing public awareness of the importance of the consumption of this whole grain commodity in the prevention of cancer and cardiovascular disease. In North America, approximately 1 in 8 women will develop breast cancer and will receive treatment with chemotherapy. Although women with breast cancer are at risk of developing heart failure due to chemotherapy, FLX has the capacity to prevent this. The purpose of the CANFLAX study is to establish FLX “milk” as an effective method in preventing heart failure in women with breast cancer. Researching the health benefits of FLX “milk” in this study will help generate: i) an increase in consumer interest; ii) an increase in the demand for FLX, and iii) an increase in FLX acreage within Manitoba. Overall, Manitoba produced FLX “milk” is an ideal product to prevent broken hearts in women with breast cancer.

3. MATCH 40 Study [Marathon Coronary Computed Tomography Angiography (CCTA) in Healthy Runners Over 40]

Marathon running has become increasingly more popular over the past two decades in Manitoba and Canada. Although 40,000 individuals participated in Canadian marathons in 1980, this number has increased to 1.5 million individuals in recent years. The increase in marathon participation has been driven mainly by increased public awareness of the health benefits associated with regular physical exercise. Despite the increased understanding of the acute cardiovascular effects of repeated marathon running, the number of participants who experience sudden cardiac death (SCD) during races continues to make headlines and draw media attention to the concerns regarding the potential health risks associated with marathon running. The objective of the MATCH 40 study is to characterize the prevalence of silent coronary artery disease using a cardiac computed tomography (CCT) in a marathon population over 40 years of age in Manitoba. This study will provide important data on the prevalence of silent heart disease in the Manitoba marathon population, with the overall goal of incorporating cardiac CT as a simple non-invasive tool for addressing the safety of endurance running in older individuals in Canada.

About Dr. Davinder S. Jassal

Dr. Jassal was born in Thompson, Manitoba, Canada, obtained an International Baccalaureate Degree at Sisler High School in Winnipeg, and graduated from the University of Manitoba with an MD in 1998. He completed a residency in Internal Medicine at the University of Manitoba from 1998-2001 and a residency in Adult Cardiology at Dalhousie University in Halifax, Nova Scotia, Canada. Subsequently, he completed a clinical and research fellowship in Cardiac Imaging specializing in echocardiography, CT, and MRI at Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Dr. Jassal joined the Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences at the University of Manitoba in 2006 as an Academic Clinician Scientist, where half of his time is devoted to patient care in CCU and cardiac imaging and the other half devoted to translational research in the field of Cardio-Oncology. He is currently Full Professor of Medicine, Radiology, and Physiology and Pathophysiology. As Head of the Section of Cardiology in the Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, at the University of Manitoba, Dr. Jassal is also the Principal Investigator of the Cardiovascular Imaging Laboratory as a member of the Institute of Cardiovascular Sciences.

For more information, please contact:

Dr. Davinder S. Jassal
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. (204) 237-2599
Lab Office. (204) 235-3056
Hospital Office. (204) 237-2023
Fax. (204) 233-2157
Email. djassal@sbgh.mb.ca

Mr. David YC Cheung
Research Technician
Rm. 4010, St. Boniface Hospital Research, 351 Tache, R2H 2A6
Lab Phone. (204) 237-2599, (204) 235-3741
Fax. (204) 233-6723
Email. dcheung@sbrc.ca

2019      

Morissette MP, Susser SE, Stammers AN, Moffatt TL, Wigle JT, Wigle TJ, Netticadan T, Premecz S, Jassal DS , O’Hara KA, Duhamel TA. Exercise-induced increases in the expression and activity of cardiac sarcoplasmic reticulum calcium ATPase 2 is attenuated in AMPKα2 kinase-dead mice. Can J Physiol Pharmacol. 2019 Jun 25:1-10.

 Abdelfatah N, Chen R, Duff HJ, Seifer CM, Buffo I, Huculak C, Clarke S, Clegg R, Jassal DS, Gordon PMK, Ober C; Care4Rare Canada Consortium, Frosk P, Gerull B. Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2. JACC Basic Transl Sci. 2019 Apr 29;4(2):204-221.

Chu K, Asselin CY, Buffo I, Lane M, Ludwig L, Jassal DS, Schantz D. The role of cardiac magnetic resonance imaging in severe anorexia nervosa. Cureus. 2019 Mar 11;11(3):e4229.

Luu J, Boston-Griffiths E, Zhu A, Jassal DS, Minhas K. Colossal left ventricular apical thrombus. Clin Case Rep. 2019 Mar 3;7(4):846-848.

Mozolevska V, Schwartz A, Cheung D, Goyal V, Shaikh B, Dingman B, Kim E, Mittal I, Asselin CY, Edel AL, Ravandi A, Thliveris J, Singal PK, Czaykowski P, Jassal DS. Role of renin-angiotensin system antagonists in the prevention of bevacizumab and sunitinib mediated cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2019 Mar1;316(3):H446-H458.

Nohla LF, Abdelmoneim SS, Villarraga R, Kohli M, Grothey A, Bordun KA, Cheung M, Best R, Cheung D, Huang R, Barros-Gomes S, Pitz M, Singal PK, Jassal DS, Mulvagh SL. Echocardiographic assessment for the detection of cardiotoxicity due to vascular endothelial growth factor inhibitor therapy in metastatic renal cell and colorectal cancers. J Am Soc Echocardiogr. 2019 Feb;32(2):267-276.

Koleini N, Santiago JJ, Nickel BE, Sequiera GL, Wang J, Fandrich RR, Jassal DS, Dhingra S, Kirshenbaum LA, Cattini PA, Kardami E. Elimination or neutralization of endogenous high molecular weight FGF2 mitigates Doxorubicin induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H279-H288.

Ho J, Toleva O, Jassal DS, Khoo C. Atypical Cardiac Manifestations of Systemic Myositis. J Clin Rheumatol. 2019 Jan 18. doi: 10.1097/RHU.0000000000000992.

Yeang C, Hasanally D, Que X, Hung MY, Stemankovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DYC, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. Reduction of myocardial ischemia-referfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 Jan 1;115(1):179-189.

2018

Arcinas LA, Yan W, Jassal DS, Love MP, Yamashita MH, Elbarouni B. Multimodality Imaging of a Giant Right Coronary Artery Aneurysm. Can J Cardiol. 2018 Dec;34(12):1688.e5-1688.e7.

Zeglinski M, Moghadam AR, Ande S, Sheikholeslami K, Mokarram P, Sepehri Z, Rokni H, Mohtaram NK, Poorebrahim M, Masoom A, Toback M, Sareen N, Saravanan S, Jassal DS, Hashemi M, Marzban H, Schaafsma D, Singal P, Wigle J, Czubryt M, Akbari M, Dixon I, Ghavami S, Gordon J, Dhingra S. Myocardial Cell Signaling During the Transition to Heart Failure. Comprehensive Physiology. 2018 Dec 13;9(1):75-125.

Sharma R, Hiebert B, Cheung D, Jassal DS, Minhas K. Primary coronary intervention in octogenerians and nonagenerians with ST-segment elevation myocardial infarction: a Canadian single-center perspective. 2018 Sep;69(8):718-723.

Dawe DE, Ye X, Czaykowski P, Jassal DS, Singh H, Skarsgard D, Aprikian A, Mahmud SM. The effect of statin use on the incidence of prostate cancer: a population-based nested case-control study. Int J Cancer. 2018 Jul 1;143(1):190-198

Donald S, Bews H, Asselin C, Elbarouni B, Allen D, Kass M, Sookhoo S, Jassal DS. The long road to the left main: a multidisciplinary approach to the revascularization of complex left main coronary artery disease. 2018 Mar 6;10(3):e2281.

2017

Bews H, Strzelczyk J, Luqman Z, Jassal DS. Multimodality imaging of a right atrial blood cyst. Eur Heart J. 2017 Dec 21;38(48):3603

Lother SA, Jassal DS, Lagace-Wiens P, Keynan Y. Emerging Group C and G Streptococcal endocarditis: a Canadian perspective. Int J Inf Dis. 2017 Dec;65:128-132

Akolkar G, da Silva Dias D, Ayyappan P, Bagchi AK, Jassal DS, Salemi VMC, Irigoyen MC, De Angelis K, Singal PK. Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H795-H809

Bagherli A, Bews H, Vo M, Ducas J, Jassal DS, Ravandi A. Iatrogenic great cardiac vein anastomosis during coronary artery bypass surgery. Int J Angiol. 2017 Sep;26(3):201-204

Karlstedt E, Jassal DS, Kirkpatrick IDC, Freed D, Seifer CM. Multimodality cardiac imaging of infective endocarditis. J Cardiovasc Med. 2017 Sep;18(9):729-730

Tangri N, Ferguson T, Whitlock R, Rigatto C, Jassal DS, Kass M, Toelva O, Komenda P. Long term health outcomes in patients with a history of mycocardial infarction: a population based cohort study. PLOS ONE. 2017 Jul 12;12(7):e0180010

Klassen JR, Jassal DS, Memauri B, Kass M, Tam JW, Windram J, Ross D, Shaikh N. Venous diversion surgery revisited: a baffling situation. 2017 Jun 6;9(6):e1320

Lau L, Mozolevska V, Kirkpatrick IDC, Jassal DS, Kansara R, Diffuse large b-cell lymphoma mimicking cardiac amyloidosis. Clin Case Rep. 2017 Apr 17;5(6):1034-1035

Akolkar G, Bagchi A, Ayyappan P, Jassal DS, Singal PK. Doxorubicin induced nitrosative stress is mitigated by Vitamin C via the modulation of nitric oxide synthases. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C418-C427

Pituskin E, Mackey JR, Koshman S, Jassal DS, Pitz M, Haykowsky MJ, Pagano JJ, Chow K, Thompson RB, Vos LJ, Ghosh S, Oudit GY, Ezekowitz JA, Paterson DI. Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101-Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity. J Clin Oncol. 2017 Mar 10;35(8):870-877

Sharma R, Golian M, Shah P, Jassal DS, Shaikh N. Multimodality cardiac imaging of a left ventricular papillary fibroelastoma: a case report. BMC Res Notes. 2017 Jan 7;10(1):25

Sharma R, Hiebert B, Cheung D, Jassal DS, Minhas K. Primary coronary intervention in octogenerians and nonagenerians with ST-segment elevation myocardial infarction: a Canadian perspective. 2017 Jan 1:3319717746520

2016

Goyal V, Bews H, Cheung D, Premecz S, Mandal S, Shaikh B, Best R, Bhindi R, Chaudhary R, Ravandi A, Thliveris J, Singal PK, Niraula S, Jassal DS. The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab-Mediated Cardiac Dysfunction. Can J Cardiol. 2016 Dec;32(12):1513-1519.

Le May M, van Diepen S, Liszkowski M, Schnell G, Tanguay JF, Granger CB, Ainsworth C, Diodati JG, Fam N, Haichin R, Jassal D, Overgaad C, Tymchak W, Tyrrell B, Osborne C, Wong G. From coronary care units to cardiac intensive care units: recommendations for organizational, staffing, and educational transformation. Can J Cardiol. 2016 Oct;32(10):1204-1213.

Virani SA, Dent S, Brezden-Masley C, Clarke B, Davis MK, Jassal DS, Johnson C, Lemieux J, Paterson I, Sebag IA, Simmons C, Sulpher J, Thain K, Thavendiranathan P, Wentzell JR, Wurtele N, Côté MA, Fine NM, Haddad H, Hayley BD, Hopkins S, Joy AA, Rayson D, Stadnick E, Straatman L. Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy. Can J Cardiol. 2016 Jul;32(7):831-41.

Goyal V, Jassal DS, Dhalla NS. Pathophysiology and prevention of sudden cardiac death. Can J Physiol Pharmacol. 2016 Mar;94(3):237-44.

Zeglinski M, Roche P, Hnatowich M, Jassal DS, Wigle J, Czubryt M, Dixon IM. TGFβ1 regulates scleraxis expression in primary cardiac myofibroblasts by a Smad-independent mechanism. Am J Physiol Heart Circ Physiol. 2016 Jan 15;310(2):H239-49.

Liu S, Moussa M, Wassef AW, Hiebert BM, Hussain F, Jassal DS. The utility of systolic and diastolic echocardiographic parameters for predicting coronary artery disease burden as defined by the SYNTAX score. 2016 Jan;33(1):14-22.

Mozolevska V, Schwartz A, Cheung D, Shaikh B, Bhagirath KM, Jassal DS. Addison’s disease and dialated cardiomyopathy: a case report and review of the literature. Case Rep Cardiol. 2016;2016:4362514.

Allen D, Bews H, Vo M, Kass M, Jassal DS, Ravandi A. Ateria Lusoria: an anomalous finding during right transradial coronary intervention. Case Rep Cardiol. 2016;2016:8079856.

Chelvanathan A, Allen D, Bews H, Ducas J, Minhas K, Vo M, Kass M, Ravandi A, Tam J, Jassal DS, Hussain F. Renal insufficiency and early bystander CPR predict in-hospital outcomes in cardiac arrest patients undergoing mild therapeutic hypothermia and cardiac catheterization: return of spontaneous circulation, cooling, and catheterization registry (ROSCCC registry). Cardiol Res Pract. 2016;2016:879826.

2015

Blackwood DP, Lavallee RK, Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of Ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159.

Holmes S, Kirkpatrick ID, Zelop CM, Jassal DS. MRI evaluation of maternal cardiac displacement in pregnancy: implications for cardiopulmonary resuscitation. Am J Obstet Gynecol. 2015 Sep;213(3):401.e1-5.

Bordun KA, Premecz  S, daSilva M, Mandal S, Goyal V, Glavinovic T, Cheung M, Cheung D, White CW, Chaudhary R, Freed DH, Villaraga HR, Herrmann J, Kohli M, Ravandi A, Thilveris J, Pitz M, Singal PK, Mulvagh SL, Jassal DS. The utility of cardiac biomarkers and echocardiography for the early detection of Bevacizumab and Sunitinib mediated cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H692-701.

Kinley DJ, Lowry H, Katz C, Jacobi F, Jassal DS, Sareen J. Depression and anxiety disorders and the link to physician diagnosed cardiac disease and metabolic risk factors. Gen Hosp Psychiatry. 2015 Jul-Aug;37(4):288-93.

Rech L, Premecz S, Jassal DS, Zahradka P, Taylor C. Dietary analysis of full marathon runners over 50 years of age: a retrospective study. J Sports Med Phys Fitness. 2015 Jun;55(6):615-20.

McIntyre WF, Jassal DS, Morris AL. Pericardial effusions: do they all require pericardiocentesis? Can J Cardiol. 2015 Jun; 31(6); 812-5.

Friesen T, Jassal DS, Zhu M, Eng F, Rigatto C, Tangri N, Sood MM, Karlstedt E, Premecz S, Komenda P. Cardiovascular remodeling during long-term nocturnal home hemodialysis. Clin Exp Nephrol. 2015 Jun;19(3):514-20

Akolkar G, Bhullar N, Bews H, Shaikh B, Premecz S, Bordun KA, Cheung DY, Goyal V, Sharma AK, Garber P, Singal PK, Jassal DS. The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicity. Cardiovasc Ultrasound. 2015 Apr 3;13(1):18

Lau L, Ducas R, Rizkallah J, Jassal DS, Seifer CM. The utility of pocket-sized echocardiography to assess left ventricular systolic function prior to permanent pacemaker implantation. Cardiovasc Ultrasound. 2015 Mar 14;13:10

Goyal V, Bews H, Shaikh N, Hussain F, Jassal DS. Multimodality cardiac imaging of a left ventricular thrombus: a case report. BMC Res Notes. 2015 Feb 28;8:59

Karlstedt E, Jassal DS, Kirkpatrick ID, Freed D, Seifer CM. Multimodality cardiac imaging of infective endocarditis. J Cardiovasc Med (Hagerstown). 2015 Jan;16 Suppl 2:S92-3.

Zeglinski MR, Hnatowich M, Jassal DS, Dixon IMC. SnoN as a Novel Negative Regulator of TGF-β/Smad Signaling:  A Target for Tailoring Organ Fibrosis. AJP eart Circ Rev. 2015 Jan;308(2):H75-82.

2018

Canadian Society of Clinical Investigation/Royal College of Physicians and Surgeons of Canada Henry Friesen Award and Lecture

2016

Doctors Manitoba Scholastic Award for scholarly activity in the health professionals

2015

Morley Lertzman Teaching Award, Department of Internal Medicine, University of Manitoba

Research Manitoba Mid-Career Research Award

Manitoba Medical Student’s Association Med I Teaching Innovation Award

Heart and Stroke Foundation of Canada 2019-2022

Title: Flaxseed in the prevention and treatment of anthracycline and trastuzumab mediated cardiotoxicity

 

Canadian Agriculture Partnership/Ag Action Manitoba 2019-2022

Title: Flaxseed prevents broken hearts in breast cancer (CANFLAX) study

 

CancerCare Manitoba RIOH Summer Studentship funding 2019

Title: Flaxseed prevents broken hearts in breast cancer (CANFLAX) study

 

Canadian Cancer Society/CIHR Grant Innovation (Co-Applicant) 2018-2020

Title: Exercise to prevent AnthraCycline-based Cardio-Toxicity (EXACT 2.0) in individuals with breast cancer

 

Molson Women’s Heart Health Research Competition 2018-2020

Title: Reducing cardiovascular risk in women with breast cancer

 

Catholic Health Corporation of Manitoba Studentship funding 2018

Title: Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity (FANTAM) study

 

CancerCare Manitoba RIOH Summer Studentship funding 2018

Title: Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity (FANTAM) study

 

Jewish Foundation of Manitoba Women’s Endowment Fund 2017-2018

Title: The art of detecting broken hearts in women with breast cancer

 

University Collaborative Research Program (UCRP) 2018-2020

Title: Role of cardiac CT for risk stratification in the marathon population

 

CancerCare Manitoba Operating Grant 2017-2019

Title: Flaxseed in the mitigation of anthracycline and trastuzumab mediated cardiotoxicity (FANTAM) study

 

Diagnostic Services Manitoba 2017-2019

Title: Scleraxis as a biomarker for cardiac fibrosis in hypertrophic cardiomyopathy

 

CIHR Operating grant (Co-applicant) 2015-2020

Title: The role of FGF2 isoforms in cardiac remodelling

 

Research Manitoba Mid-Career Research Grant 2015-2019

Title: The prophylactic role of renin-angiotensin system antagonists in the prevention of Avastin and Sutent mediated cardiotoxicity

 

CancerCare Manitoba Operating Grant 2015-2017

Title: The art of preventing broken hearts in colorectal and renal cell cancer

 

 University Research Grants Program 2014-2015

Title: Avastin and Sutent mediated Cardiotoxicity study (ASICS)

 

CancerCare Manitoba Operating Grant 2013-2015

Title: The impact of Doxorubicin and Trastuzumab on cardiac cytoarchitecture and function: insights into the prevention of chemotherapy mediated cardiotoxicity in breast cancer

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