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Clinical Research

Bringing Discoveries to the "Bedside"

Dr. Rizwan A. Manji

Dr. Rizwan A. Manji

Cardiac Surgeon

Assistant Professor
Surgery, University of Manitoba


Healthcare professionals undertake many diagnostic and therapeutic interventions. It is important to know what the outcomes are of patients with the various measures undertaken, to help determine best methods of care and best methods of healthcare resource utilization. Dr. Manji’s current clinical research interests include outcomes research of cardiac surgery and critical care patients. Areas being examined include: outcomes of elderly patients post cardiac surgery, outcome changes over time in cardiac surgery patients, effect of wait times for cardiac surgery, staffing models for critical care, heparin induced thrombocytopenia in cardiac surgery patients, seizure post cardiac surgery, cost analysis studies for alternate therapies in cardiac surgery patients, and extra-corporeal support for patients with respiratory failure. These and future studies will help guide clinicians in the care of their patients, as well as administrators in ways to use healthcare resources.

Valve surgery is the second most common cardiac surgical procedure. Young patients often receive mechanical valves, obliging them to take powerful blood thinners, placing them at risk for bleeding. If the patients do not take the blood thinners, then they may clot their valve. Animal tissue valves are not used in young patients as they break down too quickly; possibly related to a more aggressive form of inflammation in young people due to this foreign tissue – resulting in calcification. Dr. Manji does collaborative basic science research looking at the role of mitigating inflammation in tissue heart valves and seeing if this decreases calcification and improves durability of the valves.


Manji RA, Bell DD, Jacobsohn E, Singal RK, Arora RC, Zivot JB, Menkis AH. Consistent outcomes despite sicker prolong stay ICU patients – A measure of improved quality of care? Crit Care Med 2009. Vol 37(12) p. A370.

Manji RA, Jacobsohn E, Grocott H, Zivot J, and Menkis AH. Prolonged in-hospital wait times do not affect outcomes for urgent coronary artery bypass surgery. Can J Cardiol 2009, Vol 25 Suppl B p. 83B.

Manji RA, Witt J, Bell DD, Menkis AH, Zivot J, Jacobsohn E. Unfractionated heparin is the least costly method of routine deep venous thrombosis prophylaxis after cardiac surgery in a model considering the diagnosis, treatment and management of heparin induced thrombocytopenia. Can J Cardiol 2009 Vol 25 Suppl B p.159B.

Manji RA Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA. Rajotte RV, Koshal A, Ross DB. Glutaraldehyde-fixed Bioprosthetic heart valve conduits calcify and fall from xenograft rejection. Criculation 2006; 114:318.

Kumar K, Zarychanski R, Bell DD, Manji RA, Zivot J, Menkis AH, Arora RC. The Impact of 24 hour in-house intensivist coverage on a dedicated cardiac surgery ICU. Annals of Thoracic Surgery 2009 Oct 88 (4): 1153-61.

Freed D, Henzler D, White C, Fowler R, Zarychanski R, Hutchison JS, Arora R, Manji R, Legare J-F, Drews T, Veroukis S, Kesselman M, Guerguerian A-M, Kumar A.Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth. 2010; Jan. 16 (Epub ahead of print).


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