In Detail

Role of Oxidized phospholipids in ischemia reperfusion injury:

Cardiovascular disease remains one of the leading causes of morbidity and mortality worldwide. One unifying mechanistic component is the role of inflammation in its initiation and progression. For many years lipids were considered to be only cellular building blocks with very little biological activity. Due to their susceptibility to oxidation they are modified in the presence of reactive oxygen species. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPL) acquire novel biological activities not characteristic of their unoxidized precursors. The effects of OxPLs described in vitro and in vivo suggest their potential relevance in different pathologies, including atherosclerosis, acute inflammation, lung injury, and many other conditions. The actions of OxPL can vary depending upon the specific species of phospholipid being oxidized. Recently, oxidized phosphatidylcholines (OxPC) have been recognized as not only products of oxidative damage but also mediators of its progression. These compounds exert their biological activity through multiple pathways. They have been shown to be potent stimulators of platelet activating factor receptor, prostaglandin receptors and PPAR receptors resulting in platelet aggregation, induction of the coagulation cascade and apoptosis and cell death. Recent advancements in softer methods of ionization, such as electrospray mass spectrometry, has allowed us to identify and quantitate OxPL’s in biological tissues. Our group has over the past decade developed mass spectrometric techniques that can identify and quantitate oxidized lipids within atherosclerotic plaques, oxidized Low Density Lipoprotein (OxLDL), and other biological tissues. As we move forward in trying to better understand the role of OxPL in cardiovascular pathology, it necessitates a detailed understanding of the oxidized lipidome within cardiac tissue such as ischemic myocardium or in plasma from patients with acute coronary syndromes. Using this knowledge as a platform, we are investigating the role of OxPL in cardiovascular pathology and will be able to tailor therapies to prevent OxPL induced injury.

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20. Sin SP, Jassal DS, Luqman Z,  Kirkpatrick ID, Ravandi A, Kass M.  Tear in my Heart: a multimodality perspective. CJC Open 2020 DOI:https://doi.org/ 10.1016/j.cjco 2020.09.02.
21. Pascoe CD, Jha A, Ryu MH, Ragheb M, Basu S,  Stelmack G, Kindrachuk J, Gauvreau GM, O’Byrne PM, Ravandi A, Carlsten C, Halayko AJ. Allergen inhalation generates pro-inflammatory oxidized phosphatidylcholine associated with airway dysfunction. (2020) Europe Respiratory Journal (In press) (IF 12.9) 
22. Asselin C, Lam A, Cheung DYC, Eekhoudt CR,  Zhu A,  Mittal I, Mayba A, Solati Z, Edel A, Austria JA, Aukema H,  Ravandi A, Thliveris J, Singal PK; Pierce G,  Niraula S, Jassal DS. The cardioprotective role of flaxseed in the prevention of doxorubicin and trastuzumab mediated cardiotoxicity in C57Bl/6 mice.  (2020) The Journal Nutrition Jun 8:nxaa144. doi: 10.1093/jn/nxaa144.
23. Kass M, Love MP, Ravandi A. Zero Contrast Shockwave Angioplasty Facilitated by Intravascular Ultrasound. (2020) Cardiovasc Revasc Med. Apr;36(4):554-563. doi: 10.1016/j.cjca.2019.09.021.
24. Shah A, Shaikh N, Ravandi A, Kass M. Role of invasive hemodynamic assessment during trans-catheter paravalvular leak interventions.  (2020) Circulation Journal. 25;84(3):531. doi: 10.1253/circj.CJ-19-0895.
25. Bagchi AK, Surendran A, Malik A, Jassal DS, Ravandi A, Singal PK.  IL-10 Attenuates OxPCs-Mediated Lipid Metabolic Responses in Ischemia Reperfusion Injury. (2020) Scientific Reports. Jul 21;10(1):12120. doi: 10.1038/s41598-020-68995-z.
26. Rohani L, Machiraju P, Sabouny R, Meng G, Liu S, Zhao T,  Iqbal F, Ravandi A, Wu JC,  Khan A, Shutt T, Rancourt D,   Greenway SC, Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy. (2020)  Canadian Journal of Cardiology   Apr;36(4):554-563. doi: 10.1016/j.cjca.2019.09.021. Epub 2019 Oct 9.)
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2011
Society for Cardiac Angiography and Interventions. C3 Summit Finalist, Baltimore,MD, USA

2009
Gold Medal. Best Research Presentation McMaster University Internal Medicine Research Day.

2008
Chief Cardiology Fellow. McMaster University.

2006
Outstanding Chief Medical Resident. Department of Medicine. McMaster University

2005
Outstanding PGY2. Department of Medicine. McMaster University

2001
Pharmaceutical Manufacturers of Canada Research Fellowship

2000
Pharmaceutical Manufacturers of Canada Research Fellowship

1999
Stuart Allan Hoffman Award, Best Ph.D. thesis. Department of Laboratory Medicine & Pathobiology, University of Toronto
Best presentation, AOCS Annual meeting among 1500 presentations, Orlando

1998
Young Investigator Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology
Ontario Graduate Scholarship

1998
Dutkevich Foundation Award.
University of Toronto Doctoral Open Fellowship