Dr. Ashish H. Shah
Principal Investigator
Precision Medicine, Institute of Cardiovascular Sciences
Research Focus
Hemodynamics is a state of the continuum, unique to each individual, and represents an intricate and finely balanced relationship between the cardiovascular, neuro-hormonal and autonomic systems. Dr. Shah’s research focuses on resting and exercise augmented hemodynamic, and its impact on outcomes among individuals with a range of cardiovascular conditions. His expertise in the hemodynamic evaluation of adult patients with congenital – structural heart disease and research interest are well aligned. Dr. Shah has established the “invasive hemodynamic evaluation program” at the St Boniface Hospital, the first of its kind in Western Canada. Such evaluation plays a vital role in the diagnosis and management of patients with heart failure with preserved ejection fraction (HFpEF), exercise-induced pulmonary hypertension, stiff left atrial syndrome as well as patients with physical deconditioning. As it is not feasible to evaluate some patients by repeated invasive hemodynamic evaluation to identify interval change or impact of therapeutic interventions; Dr. Shah’s laboratory is exploring various alternative technologies that can provide hemodynamic parameters non-invasively. Recently, Dr. Shah’s laboratory has validated one such non-invasive technology, incorporating total body impedance principles, and will be using it in the forthcoming research projects. Incorporating such approaches, our research program is focusing on developing evidence-based interdisciplinary pathways using hemodynamic evaluation in routine clinical care and management of patients with cardiovascular conditions.
Hemodynamic deterioration leads to multi-organ dysfunction through a range of biochemical alterations at the cellular level. Our research also focuses on identifying these cellular mechanisms that will allow us to understand the involved mechanisms and potential therapeutic targets.
About Ashish H. Shah
Dr. Shah obtained MBBS and MD (Internal Medicine) from the B J Medical College, New Civil Hospital, Gujarat University, Ahmedabad, India. As per the bed capacity, the New civil hospital is the largest hospital in Asia and 3rd in the world. Dr. Shah ranked in the first 100 among 56,000 students appearing for the board exams. He was awarded the national merit scholarship for his medical school years. After working as an assistant professor for 3 years in the New Civil Hospitals, Ahmedabad and Surat, he moved to the UK to pursue further studies. After obtaining the Membership of Royal College of Physicians and Surgeons (MRCP), UK, he obtained “Doctor in Medicine” (MD-Research) from the King’s College London. His research project entitled “vascular endothelial and platelet function in heart failure”.
Dr. Shah completed a fellowship in general and interventional cardiology from the Wales Higher Training program in 2013. He pursued 3 additional years of fellowships in adult congenital, structural and coronary artery disease interventions from the Toronto General Hospital. After working as an interventional cardiologist in the Manchester Royal Infirmary, one of the largest European Adult Congenital Heart Disease centers, he has moved to Winnipeg as an interventional cardiologist. He has joined as a clinician-scientist, with a research focus on “Hemodynamics and Outcomes”.
Current Clinical Role
Dr. Shah joined the Cardiac Sciences Program and the Section of Cardiology as an Academic Clinician Scientist in 2017, where he dedicates a large proportion of time towards translational and clinical research. As a clinician, he is focusing on diagnostic and interventional procedures in patients with coronary, structural and congenital heart diseases.
Current Research Initiatives
Dr. Shah’s research interest in hemodynamic evaluation has inspired novel research projects evaluating cardiogenic shock or identification of hemodynamic parameters among patients presenting with ST-Elevation Myocardial Infarction as well as heart failure. Meticulously designed studies to replicate the pragmatic conditions while assessing the non-invasive hemodynamic measurements to widen the knowledge translation of outcomes to change the clinical practice of such cardiac patients’ management. Our approach focuses on establishing an individual patient-centric “precision medicine” approach with the intention to improvise current clinical care and outcomes.
Furthering Peer-Reviewed Research
Over the last five years, Dr. Shah has also contributed to peer reviewer responsibilities for many scientific journals such as the Canadian Journal of Cardiology, Annals of Internal Medicine, European Heart Journal – Quality of care & clinical outcomes, Heart, Lung & Circulation, Annals of Internal Medicine, and Journal of General Internal Medicine.
Dr. Shah has been invited as a faculty to present his research work in various international conferences, including TCT, CRT, and CSI-UCSF. He is also the recipient of various travel grants to attend and present his work at various international conferences.
Dr. Shah is a member of the Adult Congenital Heart Disease Learning Centre and has played a vital role in preparing various interventional procedural-learning modules.
Innovation
Dr. Shah has a special interest in BioDesign and innovation. One of his devices focusing on obtaining patent radial hemostasis is under review for the European patent rights.
Application No.: US14/575,141, application Date: Dec 18, 2014.
For more information, please contact:
Dr. Ashish H. Shah
Y3006 – St. Boniface Hospital
409 Taché Avenue
Winnipeg, MB R2H 2A6
Phone: (204) 237-2315
Fax: (204) 233-2157
Email: ashah5@sbgh.mb.ca
Lab Address:
Room 3020, I.H. Asper Institute, St. Boniface Hospital
St. Boniface Hospital
409 Taché Avenue
Winnipeg, MB R2H 2A6
Selected Publications
Transcatheter closure of a secundum atrial septal defect in the presence of anomalous pulmonary veins. Shah AH, Bach Y, Osten M, Benson L, Abrahamyan L, Horlick E JACC: Cardiovascular Interventions (accepted – July 2020)
Long-Term Mortality Following Transcatheter Atrial Septal Defects Closure in Comparison to the General Population Alnasser S; Lee DS; Osten M; Austin PC; Shah A; Bach Y; Abrahamyan L; Yu B; Benson L; Horlick EM JACC (accepted – May 2020) (PMID: 32703520)
Is hypoxia in standing position mandatory in defining platypnea orthodeoxia syndrome? Shah AH; Kass M; Carroll J JACC: Cardiovascular Interventions (accepted June 2020) (PMID: 32739302)
Augmentation of Pulmonary Blood Flow and Cardiac Output by Non-invasive External Ventilation Late After Fontan Palliation Charla P; Karur G; Yamamura K; Yoo S; Granton J; Oechslin E; Shah A; Benson L; Honjo O; Mertens L; Alonso R; Hanneman K; Wald R Heart (online ahead of print) (PMID: 32748799)
Role of invasive hemodynamic assessment during trans-catheter paravalvular leak interventions Shah AH, Shaikh N, Ravandi A, Kass M Circulation Journal 2020; 84(3):531 (PMID 31969534)
Long-term outcomes of percutaneous closure of coronary artery fistulae in the adult: A single centre experience Shah AH, Osten M, Alnasser S, Bach Y, Meier L, Horlick EM Catheterization and Cardiovascular Interventions (online before print) (PMID: 31876376)
Clinical outcomes after percutaneous patent ductus arteriosus closure in adults Wilson WM, Shah A, Osten M, Benson LN, Abraha N, Breitner D, Horlick EM Canadian Journal of Cardiology 2019;36(6):837-843 (PMID: 32536374)
Permanent pacing in a patient with Fontan circulation: Use all you have at your discretion Shah AH, Khadem A, Tam J, Ducas R Heart, Lung and Circulation, 2020 Jan 29(1):e17-18 (PMID: 31547962)
Management of cardiogenic shock complicating acute myocardial infarction: A review Shah AH, Puri R, Kalra A Clinical Cardiology 2019 Apr; 42(4):484-493 (PMID: 30815887)
Long Term Outcomes Among Adults Post Transcatheter Atrial Septal Defect Closure: Systematic Review and Meta-analysis. Alnasser S, Lee D, Austin P, Labos C, Osten M, Lightfoot D, Kutty S, Shah AH, Meier L, Benson L, Horlick EM. International Journal of Cardiology 2018 Nov 1;270:126-132 (PMID: 30054146)
Incidence and outcomes of a positive bubble contrast study after transcatheter closure of a patent foramen ovale Shah AH, Osten M, Al-nasser S, Bach Y, Benson L, Horlick EM JACC: Cardiovascular Interventions 2018 Jun:11(11):1095-1104
Transcatheter valve implantation for right atrium-to-right ventricle conduit obstruction or regurgitation after modified Bjork-Fontan procedure. Shah AH, Horlick EM, Eicken A, Asnes JD, Locks ML, Boudjemline Y, Cabalka AK, Fagan TE, Schubert S, Mahadevan VS, Dvir D, McElhinney DB Catheter Cardiovasc Interv 2017 Feb 1;89(2):298-305 (PMID: 27465501)
Percutaneous intervention to treat platypnea-orthodeoxia syndrome: Toronto Experience. Shah AH, Leventhal A, Bach Y, Osten M, Wilson WM, Horlick E JACC: Cardiovascular Interventions 2016 Sep 26;9(18):1928-38 (PMID: 27659570)
A young woman with recurrent atrial fibrillation Shah AH, Delgado D, Roche L. JAMA Cardiol.2016;1(5):613-614
Uric acid bladder stones in congenital cyanotic heart disease Shah AH, Keir M, Ducas R, Crean A Lancet October 2016; 388(10054):1921(PMID: 27156932)
Ventricular fibrillation precipitated by intracoronary adenosine during fractional flow reserve assessment – A cautionary tale Shah AH, Chan W, Seidelin P Heart, Lung and Circulation 2015 Nov;24(11):e173-5 (PMID: 26166173)
Transcatheter pulmonary valve replacement with the Edwards-Sapien Valve: The Toronto experience. Wilson W, Osten M, Benson L, Shah AH, Horlick E.
JACC: Cardiovascular Interventions 2015;8(14):1819-1827 (PMID-26718514)
Letter to the editor: Re: “Prasugrel plus aspirin beyond 12 months is associated with improved outcome after Taxus Liberte paclitaxel-eluting coronary stent placement.
Shah AH, Buch AN Circulation 2015; 132: e164 (PMID: 26416637)
Worsening hypoxia post-lung-transplantation: What has changed? Shah AH, Leventhal A, Horlick E, Oechslin E, Osten M Heart, Lung and Circulation 2016 Nov;25(11):e155-e157 (PMID: 27283447)
Coronary artery fistula: Indications for treatment and technical considerations Shah AH, Leventhal A, Osten M, Benson L, Horlick E-Journal of Structural Heart Disease (Accepted, In press)
Allen’s test: Has it got a role to play in present-day practice? Shah AH, Pancholy S, Shah S, Buch AN, Patel TM Journal of Invasive Cardiology 2015; 27(5): E70-E73 (PMID: 25929307)
Radiation dose during coronary angiogram: Relation of body mass index Shah A, Das PK, Subkovas E, Buch AN, Rees M, Bellamy CM Heart, Lung and Circulation 2015 Jan; 24(1): 21-25 (PMID: 25065542)
Platelets nitric oxide signalling in heart failure patients: Role of oxidative stress. Shah A, Passacquale G, Gkaliagkousi E, Ritter J, Ferro A. Cardiovascular Research 2011; 91 (4): 625-31 (PMID: 21502370)
Endothelial function and arterial compliance are not impaired in subjects with heart failure of non-ischemic origin Shah A, Gkaliagkousi E, Ritter J, Ferro A. J Card Fail 2010; 16 (2); 114-120. (PMID: 20142022)
Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension. Gkaliagkousi E, Corrigall V, Becker S, De Winter P, Shah A, Ritter J, Ferro A. Eur Heart J 2009; 30 (24): 3048-3054 (PMID: 19687162)
Measurement of platelet ‘P’ selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Fox S C, May J A, Shah A, Neubert U, Heptinstall S Platelets, 2009; 20 (4): 250-259 (PMID: 19440925)
Age decreases nitric oxide synthesis and responsiveness in human platelets and increases the formation of monocyte-platelet aggregates. Shah A, Goubareva I, Gkaliagkousi E, Queen L R, Ritter J, Ferro A Cardiovascular Research, 2007; 75(4): 793-802 (PMID: 17572401)
2019 Invited faculty: CSI-UCSF, San Francisco, CA, USA2019 Invited faculty: CSI-UCSF, San Francisco, CA, USA
2018 Invited faculty: CRT, TCT and CSI – UCSF meetings, 2018
2011-16 Received travel grant to present research work at TCT, 2011 to 2016, USA
2011-13 Received travel grant to present research work at EuroPCR, Paris, France
2013 Staff recognition award nominee – University hospital of Wales, Cardiff, UK
2011 Associate Royal College Tutor, Royal College of Physicians, UK
2004 Research grant for doctorate in research, King’s College London, UK
2004 Membership of Royal College of Physicians (MRCP), UK
1989 National Merit Scholarship – duration of MBBS (5 years)
1. Cardiac Sciences Program (CSP) Pilot Project Awards (2019)1. Cardiac Sciences Program (CSP) Pilot Project Awards (2019) ST-elevation myocardial infarction Hemodynamic OutCome study: Role of Non-Invasive Cardiac System (SHOCk-NICaS study) ($30,000)
2. Manitoba Medical Service Foundation (MMSF) research grant (2018)Novel methods for selecting appropriate patients undergoing transcatheter aortic valve implantation (TAVI): A pilot project ($30,000)
3. Establishment grant, University of Manitoba & Cardiac Sciences Program (2018)I received funding to initiate and establish a research laboratory, at the St Boniface Hospital, Winnipeg, MB, Canada ($175,000).
4. Cardiology Research Development Fund (2018)Study entitled “Identification of novel biomarkers of disease progression in individuals with Fontan circulation” ($10,000.00)